Fig. 1

IL-1β promoted chondrocyte injury. A Cell viability in CHON-001 cells treated with different doses of IL-1β was detected by the MTT assay. B–D Cell proliferation and apoptosis in CHON-001 cells with or without IL-1β stimulation (10 ng/mL) were detected by the EdU and flow cytometry assays. E Relative protein levels of Bax and Bcl-2 in the above CHON-001 cells were evaluated by the WB analysis. F–H The levels of IL-6 and TNF-α released from the above cells and the production of MDA in these cells were analyzed with the respective kits. *P < 0.05, **P < 0.01, ***P < 0.001, and ****P < 0.0001