Fig. 6

ITGB1 improves OA symptoms in rats (N = 3). A The mRNA expression level of ITGB1 was detected by RT-qPCR. B–D Results of H&E, safranin O staining and IHC of rat cartilage tissue (Amplification: 200 × , Scale: 100 μm). E OARSI scores of articular cartilage. F Enzyme-linked immunosorbent assay (ELISA) was used to detect the levels of IL-1β, TNF-α and IL-6. ^**p < 0.01 versus Control; ^##p < 0.01, ^#p < 0.05 versus OA+LV-NC