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Fig. 3 | Journal of Orthopaedic Surgery and Research

Fig. 3

From: Exosomal miR-331-3p derived from chemoresistant osteosarcoma cells induces chemoresistance through autophagy

Fig. 3

a The inhibition curve of CDDP on drug-resistant and sensitive cells of MG63 and HOS. b The cell viability of the MG63, MG63 + Exo, and MG63 + Exo/CDDP groups (left) and the HOS, HOS + Exo, and HOS + Exo/CDDP groups (right) in the presence of 10, 30, and 60 ng/mL of cisplatin according to the MTT assay. c The cell viability in the MG63, MG63 + Exo/CDDP, and MG63 + Exo/CDDP + siRNA-Drosha (left) and HOS, HOS + Exo, HOS + Exo/CDDP, and HOS + Exo/CDDP + siRNA-Drosha (right) at 0, 12, 24, and 48 h. *P < 0.05, **P < 0.01, ***P < 0.001 versus the control group. d The expression of miR-199a in the MG63/CDDP, MG63 + Exo/CDDP, and MG63 + Exo/CDDP + GW4869 groups (left) and the HOS/CDDP, HOS + Exo/CDDP and HOS + Exo/CDDP + GW4869 groups (right). **P < 0.001 versus the MG63/CDDP and HOS/CDDP control groups. CDDP, cisplatin; Exo, exosomes; MTT, 3-[4, 5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide; siRNA, small interfering RNA

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X