Chinese medicine Gushukang capsule for treating primary osteoporosis: a systematic review and meta-analysis

Liu, Tianpeng; Yao, Menglin; Zhao, Yifan; Zhao, Shaochuan; Rui, Chen; Yang, Feng

doi:10.1186/s13018-023-04264-9

Journal of Orthopaedic Surgery and Research

Table 1 Characteristics of randomized controlled trials on GSK capsule for osteoporosis

From: Chinese medicine Gushukang capsule for treating primary osteoporosis: a systematic review and meta-analysis

Study	Sample size (T/C)	Age (years old)		Medical condition	Intervention		Duration (months)	Outcomes	Adverse events
Study	Sample size (T/C)	T	C	Medical condition	T	C	Duration (months)	Outcomes	Adverse events
Bai et al. [37]	58/57	65.5 ± 10.5	65.9 ± 11.2	Postmenopausal osteoporosis	GSK 10 g Bid + alfacalcidol 1 μg Qd	Alfacalcidol 1 μg Qd	9	④	Not mentioned
Chen 1 [38]	23/19	62.53 ± 9.24	63.21 ± 10.1	Postmenopausal osteoporosis	GSK 10 g Bid + calcium carbonate 750 mg and vitamin D₃ 100 IU Bid	Calcium carbonate 750 mg and vitamin D₃ 100 IU Bid	6	⑥⑧④⑨	Not mentioned
Chen [28]	45/45	53.4 ± 6.6	46.5 ± 8.5	Senile osteoporosis	GSK 10 g Bid + rocaltrol 0.25 μg Qd + alendronate sodium 70 mg Qw	Rocaltrol 0.25 μg Qd + alendronate sodium 70 mg Qw	6	⑦⑤⑧④	Mentioned
Cheng et al. [39]	80/80	67.07 ± 5.59	67.54 ± 5.81	Senile osteoporosis	GSK 10 g Bid + calcium carbonate 750 mg and vitamin D₃ 100 IU Bid	Calcium carbonate 750 mg and vitamin D₃ 100 IU Bid	6	⑥⑨⑧④	Not mentioned
Cong et al. [29]	53/53	62.24 ± 10.36	62.58 ± 10.66	Senile osteoporosis	GSK 1.28 g Bid + rocaltrol 0.25 μg Qd + alendronate sodium 70 mg Qw	Rocaltrol 0.25 μg Qd + alendronate sodium 70 mg Qw	6	⑦⑥⑧⑤④	Not found
Feng et al. [40]	35/31	72.6 ± 16.4	72.3 ± 14.7	Senile osteoporosis	GSK 10 g Bid + salcatonin 100 IU Qod + calcium carbonate 750 mg and vitamin D₃ 100 IU Tid	Salcatonin 100 IU Qod + calcium carbonate 750 mg and vitamin D₃ 100 IU Tid	6	⑦	Not mentioned
Guo et al. [41]	39/39	62.3 ± 3.7	62.7 ± 3.2	Postmenopausal osteoporosis	GSK 10 g Bid + alfacalcidol 0.5 μg Qd	Alfacalcidol 0.5 μg Qd	6	⑥④	Not mentioned
Li [42]	55/40	61.5 ± 12.5	61.7 ± 13.7	Senile osteoporosis	GSK 10 g Tid + calcium carbonate 600 mg and vitamin D₃ 125 IU Tid + salcatonin 20 μg Qod	Calcium carbonate 600 mg and vitamin D₃ 125 IU Tid + salcatonin 20 μg Qod	6	⑦	Not mentioned
Li [30]	60/60	56.3 ± 2.5	56.1 ± 2.4	Postmenopausal osteoporosis	GSK 10 g Bid + vitamin D₃ 100 IU and salcatonin 100 IU Qd	Vitamin D₃ 100 IU and salcatonin 100 IU Qd	6	⑦	Mentioned
Li [43]	44/41	70.21 ± 10.21	71.27 ± 10.35	Senile osteoporosis	GSK 10 g Tid + calcium carbonate 1.5 g and vitamin D₃ 125 IU Bid	Calcium carbonate 1.5 g and vitamin D₃ 125 IU Bid	3	⑦	Not mentioned
Li [44]	40/40	68.3 ± 5.7	68.5 ± 5.4	Senile osteoporosis	GSK GSK 1.28 g Bid + vitamin D₃ 100 IU Bid	Vitamin D₃ 100 IU Bid	3	⑦⑥①	Not mentioned
Lin et al. [31]	48/48	71.42 ± 3.85	71.25 ± 3.96	Senile osteoporosis	GSK 1.28 g Bid + alfacalcidol 0.5 μg Qd	Alfacalcidol 0.5 μg Qd	6	⑦⑥	Mentioned
Lu et al. [45]	40/40	68.3 ± 12.3	68.1 ± 11.2	Postmenopausal osteoporosis	GSK 12 g Tid	Nilestriol 2 mg Biw	6	⑦④⑥	Not mentioned
Ren [46]	35/30	60.21 ± 2.35	61.37 ± 1.26	Senile osteoporosis	GSK 10 g Bid + alendronate sodium 70 mg Qw	Alendronate sodium 70 mg Qw	3	⑥①	Not mentioned
Shen [32]	40/40	61.28 ± 11.7	62.12 ± 11.91	Senile osteoporosis	GSK 1.28 g Bid + calcium carbonate 750 mg and vitamin D₃ 100 IU Qd	Calcium carbonate 750 mg and vitamin D₃ 100 IU Qd	6	⑧⑥⑤	Mentioned
Shi [33]	70/70	54.3 ± 6.1	55.5 ± 6.9	Postmenopausal osteoporosis	GSK 1.28 g Bid + salcatonin 20 μg and estradiol valerate 1 mg Qd	Salcatonin 20 μg and estradiol valerate 1 mg Qd	6	⑦①⑥	Mentioned
Shi [47]	45/48	62.91 ± 2.89	62.84 ± 2.33	Senile osteoporosis	GSK 10 g Bid	Alendronate sodium 70 mg Qw	6	⑧④	Not mentioned
Wang [48]	35/35	69.04 ± 3.04	68.26 ± 2.74	Senile osteoporosis	GSK 10 g Qd	Alfacalcidol 0.5 μg Qd	6	⑧⑥⑤	Not mentioned
Wu [49]	70/70	58.2 ± 4.5	58.6 ± 4.7	Postmenopausal osteoporosis	GSK 10 g Qd + estrogen 0.625 mg Qd + vitamin D₃ 100 IU Qd	Estrogen 0.625 mg Qd + vitamin D₃ 100 IU Qd	12	⑥④	Not mentioned
Yuan et al. [50]	42/42	67.46 ± 7.89	67.38 ± 7.07	Postmenopausal osteoporosis	GSK 1.28 g Bid + rocaltrol 0.25 µg and calcium carbonate D₃ 500 mg Qd	Rocaltrol 0.25 µg Qd and calcium carbonate D₃ 500 mg Qd	6	⑥④②③	Not Mentioned
Zhang [34]	40/40	62.9 ± 3.5	60.2 ± 4.8	Senile osteoporosis	GSK 10 g Tid	Calcium carbonate 750 mg and vitamin D₃ 100 IU Tid + salcatonin 100 IU Qod	6	⑦	Mentioned
Zhang [35]	56/56	84.3 ± 6.3	85.2 ± 6.5	Senile osteoporosis	GSK 10 g Bid + alendronate sodium 70 mg Qw + rocaltrol 0.25 μg Qd + calcium carbonate 750 mg and vitamin D₃ 100 IU Bid	Alendronate sodium 70 mg Qw + rocaltrol 0.25 μg Qd + calcium carbonate 750 mg and vitamin D₃ 100 IU Bid	6	⑥①②③	Mentioned
Zhong [51]	46/46	54.2 ± 3.2	52.4 ± 2.1	Senile osteoporosis	GSK 12 g Tid + calcium carbonate 750 mg and vitamin D₃ 100 IU Bid + salcatonin 20 µg Qod	Calcium carbonate 750 mg and vitamin D₃ 100 IU Bid + salcatonin 20 µg Qod	6	⑦	Not mentioned
Zhou [36]	98/96	85.3 ± 1.6	85.7 ± 1.8	Senile osteoporosis	GSK 10 g Bid + C alendronate sodium 70 mg Qw + calcium carbonate 600 mg and vitamin D₃ 125 IU Qd	Alendronate sodium 70 mg Qw + calcium carbonate 600 mg and vitamin D₃ 125 IU Qd	12	⑦①⑥⑧④⑤	Mentioned

T, treatment group; C, control group; GSK, Gushukang capsule; Qd, once daily; Qod, once for every other day; Bid, twice daily; Tid, three times daily; g, gram; mg, milligram; μg, microgram; Qw, once per week; Biw, twice per week; ① VAS, visual analog scale; ② PINP, prepeptide of type I procollagen; ③ β-CTX, beta type I collagen carboxy-terminal peptide; ④ ALP, alkaline phosphatase; ⑤ BGP, bone glutamyl protein; ⑥ BMD, bone mineral density; ⑦ OE, overall efficiency; ⑧ S-Ca, serum calcium; ⑨ S-P, serum phosphorus

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