Fig. 4

Effects of BMP9 and Lox on HIF-1α in 3T3-L1 cells A, B Effect of BMP9 on the protein level of HIF-1α. C Effect of BAPN on the mRNA level of HIF-1α induced by BMP9. D Effect of BAPN on the protein level of HIF-1α induced by BMP9. E, F Effect of BAPN on the protein level of HIF-1α induced by BMP9. G, H Effect of siRNA of Lox on the protein level of HIF-1α induced by BMP9. I, J Effect of Lox on the protein level of HIF-1α induced by BMP9. (BAPN: β-aminopropionitrile, inhibitor of Lox, the concentration is 200 μM. *p < 0.05, **p < 0.01 vs. control; ##p < 0.01 vs. BMP9 treated group)