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Fig. 3 | Journal of Orthopaedic Surgery and Research

Fig. 3

From: Lysyl oxidase inhibits BMP9-induced osteoblastic differentiation through reducing Wnt/β-catenin via HIF-1a repression in 3T3-L1 cells

Fig. 3

Effects of Wnt/β-catenin on the osteoblastic markers, which affected by BMP9 and Lox specific inhibitor in 3T3-L1 cells. A Effect of BAPN on the mRNA level of c-Myc induced by BMP9. B, C Effect of BAPN on the protein level of β-catenin induced by BMP9. D, E Effect of BAPN and siRNA of β-catenin on the protein level of Runx2 induced by BMP9. F, G Effect of BAPN, and siRNA of β-catenin on the protein level of OPN induced by BMP9. H, I Effect of BAPN, and siRNA of β-catenin on the mineralization induced by BMP9. (BAPN: β-aminopropionitrile, inhibitor of Lox, the concentration is 200 μM. *p < 0.05, **p < 0.01 vs. control; #p < 0.01, ##p < 0.01 vs. BMP9 treated group)

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X