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Fig. 2 | Journal of Orthopaedic Surgery and Research

Fig. 2

From: Lysyl oxidase inhibits BMP9-induced osteoblastic differentiation through reducing Wnt/β-catenin via HIF-1a repression in 3T3-L1 cells

Fig. 2

Effects of Lox on the osteogenic and adipogenic markers induced by BMP9 in 3T3-L1 cells A, B Effect of BMP9 and BAPN on the Runx2 protein level. (C) The effect of BMP9 and BAPN on the matrix mineralization. D, E Effect of BMP9 and Lox knockdown on the Runx2 protein level. F Effect of BMP9 and Lox knockdown on the matrix mineralization. G, H The BMP9 and Lox effect on the Runx2 protein level. I The effect of BMP9 and Lox on matrix mineralization. J Effect of BMP9 and Lox knockdown on the protein level of C/EBPα or PPARγ. K, L BMP9 and Lox knockdown effect on the mRNA level of C/EBPα or PPARγ. (BAPN: β-aminopropionitrile, inhibitor of Lox, the concentration is 200 μM. **p < 0.01 vs. control; #p < 0.05, ##p < 0.01 vs. BMP9 treated group)

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X