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Table 2 Results of heterogeneity and horizontal pleiotropy analysis for IVs of 9 GM taxa associated with IVDD

From: Gut microbiota and intervertebral disc degeneration: a bidirectional two-sample Mendelian randomization study

Exposure

Heterogeneity test

MR-Egger intercept test

MR-PRESSO global test

MR-IVW

MR-Egger

Egger_intercept

SE

P

RSS obs

P

Family

Family Rikenellaceae id.967

Q = 14.471

Q = 14.289

 − 0.005

0.012

0.676

16.364

0.565

P = 0.564

P = 0.504

Family Ruminococcaceae id.2050

Q = 6.676

Q = 6.189

 − 0.010

0.014

0.508

8.5467

0.623

P = 0.572

P = 0.518

Genus

Genus Escherichia Shigella id.3504

Q = 7.955

Q = 7.645

 − 0.008

0.015

0.593

9.708

0.542

P = 0.539

P = 0.469

Genus Eubacterium coprostanoligenes group id.11375

Q = 7.735

Q = 6.683

0.016

0.016

0.327

9.066

0.761

P = 0.806

P = 0.824

Genus Gordonibacter id.821

Q = 6.773

Q = 6.740

0.004

0.020

0.858

8.198

0.775

P = 0.817

P = 0.750

Genus Lachnoclostridium id.11308

Q = 11.166

Q = 10.808

 − 0.009

0.014

0.562

12.955

0.517

P = 0.515

P = 0.460

Genus Marvinbryantia id.2005

Q = 6.462

Q = 6.409

 − 0.005

0.021

0.824

8.243

0.716

P = 0.693

P = 0.602

Genus Oscillospira id.2064

Q = 10.485

Q = 8.580

0.034

0.030

0.292

13.456

0.155

P = 0.163

P = 0.199

Phylum

Phylum Bacteroidetes id.905

Q = 8.994

Q = 8.994

0.000

0.011

0.991

10.871

0.564

P = 0.533

P = 0.438

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X