Association of 25-hydroxyvitamin D levels with lipid profiles in osteoporosis patients: a retrospective cross-sectional study

Table 4 Threshold effect analysis examining the relationship between 25(OH)D level and lipids

	Model II^a
	TC β (95% CI) P value	TG β (95% CI) P value	HDL β (95% CI) P value	LDL β (95% CI) P value	APO-A β (95% CI) P value	LPa β (95% CI) P value
Model A^b
One line slope	0.003 (0.003, 0.008) 0.37	− 0.006 (− 0.011, − 0.001) 0.03	0.004 (0.002, 0.006) < 0.01	− 0.001 (− 0.006, 0.003) 0.55	0.004 (0.002,0.005) < 0.01	1.33 (0.34,2.32) < 0.01
Model B^c
Serum 25(OH)D turning point (K), ng/mL	10.04	10.04	12.87	10.04	24.21	26
< K	0.11 (0.02, 0.19) 0.01	0.05 (− 0.03, 0.12) 0.26	0.000 (− 0.013, 0.014) 0.96	0.10 (0.03, 0.17) < 0.01	0.005 (0.002, 0.008) < 0.01	2.07 (0.40, 3.75) 0.02
> K	0.001 (− 0.005, 0.007) 0.82	− 0.007 (− 0.012, − 0.001) 0.01	0.004 (0.002, 0.006) < 0.01	− 0.003 (− 0.008, 0.001) 0.18	0.002 (− 0.000, 0.005) 0.07	0.45 (− 1.44, 2.34) 0.64
Slope 2–Slope 1	− 0.11 (− 0.19, − 0.02) 0.02	− 0.05 (− 0.13, 0.03) 0.20	0.004 (− 0.01, 0.02) 0.60	− 0.10 (− 0.17, − 0.03) < 0.01	− 0.003 (− 0.007, 0.002) 0.23	− 1.62 (− 4.59, 1.35) 0.28
LRT^d	0.02	0.20	0.59	0.004	0.22	0.28

Bolded data are now presented with three decimal places, which improves the sensitivity of the data
CI confidence interval, 25(OH)D 25-hydroxy vitamin D, TC total cholesterol, TG triglyceride, HDL high-density lipoprotein, LDL low-density lipoprotein, APO-A apolipoproteina, LPa lipoproteina, BMI body mass index, β-CTX beta-C-terminal telopeptide of type I collagen, P1NP procollagen type I N-terminal propeptide, LRT logarithmic likelihood ratio test
^aAdjusted for sex; age of blood collection; year of blood collection; calcium; BMI; season; main diagnosis; hypertension; diabetes; β-CTX; P1NP
^bLinear analysis, P value < 0.05 indicates a linear relationship
^cNonlinear analysis
^dP value < 0.05 means Model B is significantly different from Model A, which indicates a nonlinear relationship

ISSN: 1749-799X