Intravenous iron and erythropoietin therapy for postoperative anemia among orthopedic surgery patients

Table 5 Iron metabolism and erythropoiesis parameters

	Baseline	POD1	POD3	POD7
Control
Iron (μmol/L)	26.63 ± 3.73	15.75 ± 3.02	14.97 ± 1.82	18.78 ± 2.53
TSAT (%)	38.75 ± 3.33	29.2 ± 3.45	30.98 ± 2.89	32.49 ± 2.88
Ferritin (ng/ml)	302.1 ± 71.87	370.2 ± 97.15	390.7 ± 87.02	341.9 ± 68.09
Hepcidin (pg/ml)	66,898 ± 15,507	166,589 ± 25,313	107,156 ± 28,831	64,595 ± 21,636
Folate (nmol/L)	19.2 ± 2.22	14.25 ± 2.29	13.64 ± 2.57	16.37 ± 1.89
VitaminB₁₂ (pmol/L)	1067 ± 152	909.2 ± 162	1191 ± 150.8	1075 ± 171.3
Group 1
Iron (μmol/L)	21.03 ± 2.09	12.93 ± 3.08	11.45 ± 2.56	14.06 ± 3.6
TSAT (%)	42.26 ± 4.58	37.13 ± 4.7	29.63 ± 5.15	39.81 ± 9.43
Ferritin (ng/ml)	273.8 ± 45.44	351.1 ± 39.58	631.9 ± 61.25	861.3 ± 118.4
Hepcidin (pg/ml)	21,937 ± 3951	112,552 ± 24,534	71,852 ± 21,927	54,167 ± 15,376
Folate (nmol/L)	12.54 ± 2.38	7.92 ± 1.58	8.1 ± 0.81	10.02 ± 2.02
VitaminB₁₂ (pmol/L)	452 ± 132.4	1070 ± 204.3	1189 ± 190.5	1266 ± 210
Group 2
Iron (μmol/L)	24.79 ± 3.16	10.65 ± 1.94	9.23 ± 1.28	13.99 ± 2.24
TSAT (%)	40.04 ± 2.57	23.07 ± 6.04	21.96 ± 1.84	29.62 ± 5.08
Ferritin (ng/ml)	198.2 ± 30.47	278.2 ± 45.86	713.3 ± 69.14	857.3 ± 101.3
Hepcidin (pg/ml)	22,021 ± 4595	78,443 ± 20,413	56,820 ± 16,460	33,337 ± 7249
Folate (nmol/L)	16.46 ± 1.77	12.29 ± 2.04	11.4 ± 1.52	10.87 ± 1.45
VitaminB₁₂ (pmol/L)	1114 ± 169	1356 ± 111.2	1365 ± 111.5	1348 ± 128.1

Treatment regimens: Group 1, IV iron monotherapy; Group 2, combined IV iron and rHuEPO; and Control, placebo
POD, postoperative day; p1, Group 1 versus Control; p2, Group 2 versus Control; p3, Group 1 versus Group 2; all values are expressed as mean ± standard deviation

ISSN: 1749-799X