The effect of perioperative tranexamic acid (TXA) in patients with calcaneal fractures: a meta-analysis and systematic review of randomized controlled trials

Table 4 The results of the meta-analysis

Variables	No. of Study	No. of patients intervention	No. of patients control	Pooled data		Heterogeneity
Variables	No. of Study	No. of patients intervention	No. of patients control	SMD/Log RR (95% CI)	P	I² (%)	Ph
Clinical outcomes
Postoperative drainage volume (ml)	3	54	58	− 0.41 (− 1.05, 0.23)	0.21	81.95	< 0.001*
By subgroup (follow-up time)
0–24 h	3	54	58	− 0.99 (− 1.38, − 0.61)	< 0.001*	0	0.82
24–48 h	3	54	58	0.18 (− 0.61, 0.97)	0.65	77.92	0.01*
Intraoperative blood loss (ml)	2	81	81	− 2.78 (− 7.50, 1.94)	0.25	98.75	< 0.001*
Hospital stay (days)	2	65	65	− 1.09 (− 2.44, 0.27)	0.12	91.41	< 0.001*
Duration of surgery (mins)	2	81	81	− 0.38 (− 0.86, 0.10)	0.12	57.79	0.12
Blood tests
Hemoglobin (g/L)	4	99	103	0.77 (0.32, 1.22)	< 0.001*	54.88	0.09
Hematocrit (%)	4	99	103	0.92 (0.12, 1.73)	0.03*	85.32	< 0.001*
Platelet count (10^9/L)	4	99	103	0.04 (− 0.23, 0.32)	0.77	0	0.92
PT (s)	4	99	103	0.17 (− 0.32, 0.65)	0.50	63.42	0.05*
APTT (s)	4	99	103	0.08 (− 0.20, 0.36)	0.57	0	0.64
Complications
Wound complications	2	75	61	− 1.10 (− 2.17, − 0.02)	0.04*	0	0.52

APTT activated partial thromboplastin time, PT Prothrombin time. * indicates statistically difference

ISSN: 1749-799X