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Table 2 Univariable and multivariable logistic regression models in patients with osteosarcoma predicting chemotherapy

From: Survival benefits and challenges of adjuvant chemotherapy for high-grade osteosarcoma: a population-based study

 

Univariable

Multivariable

HR

95% CI

p

HR

95% CI

p

Age

 0–10 year

Reference

   

Reference

   

 11–20 year

1.21

0.51

2.86

0.67

1.217

0.512

2.894

0.656

 21–40 year

0.22

0.1

0.5

 < 0.001

0.258

0.111

0.6

0.002

 41–60 year

0.09

0.0

0.19

 < 0.001

0.113

0.047

0.272

 < 0.001

  > 60year

0.03

0.01

0.06

 < 0.001

0.039

0.016

0.097

 < 0.001

Sex

 Male

Reference

       

 Female

0.95

0.74

1.23

0.72

    

Race

 White

Reference

       

 Black

1.11

0.76

1.61

0.59

    

 Other

0.95

0.62

1.44

0.79

    

Marital

 Married

Reference

   

Reference

   

 Single

0.17

0.12

0.22

 < 0.001

1.11

0.727

1.695

0.628

 Divorced, Separated, Widowed, Unmarried or Domestic Partner or unknown

0.07

0.05

0.1

 < 0.001

0.656

0.389

1.106

0.114

Mean family income

  > $74,999

Reference

       

 $60,000–$74,999

1.15

0.84

1.56

0.38

    

  < $60,000

1.15

0.82

1.62

0.43

    

Rural or urban

 Counties in metropolitan areas ge 1 million pop

Reference

       

 Other

1.13

0.87

1.47

0.36

    

Primary site

 Limbs

Reference

   

Reference

   

 Pelvic bones, sacrum, coccyx and associated joints

0.26

0.18

0.38

 < 0.001

0.855

0.534

1.37

0.516

 Bones of skull and face and associated joints/Mandible

0.18

0.13

0.26

 < 0.001

0.445

0.296

0.669

 < 0.001

 Vertebral column/Rib, sternum, clavicle and associated joints

0.18

0.11

0.29

 < 0.001

0.479

0.281

0.816

0.007

 Unknown

0.1

0.03

0.3

 < 0.001

0.379

0.101

1.422

0.151

Laterality

 Left

Reference

       

 Right

0.99

0.73

1.33

0.92

    

 Not a paired site or unknown

0.22

0.16

0.31

 < 0.001

    

T

 T1

        

 T2

1.59

1.11

2.27

0.01

    

 T3

0.96

0.42

2.21

0.93

    

 TX

0.75

0.55

1.03

0.07

    

N

 N0

Reference

   

Reference

   

 N1

0.81

0.31

2.1

0.66

1.035

0.352

3.037

0.951

 NX

0.59

0.46

0.77

 < 0.001

0.291

0.146

0.58

 < 0.001

M

 M0

Reference

   

Reference

   

 M1

0.99

0.67

1.46

0.96

1.446

0.88

2.376

0.146

 MX

0.71

0.53

0.94

0.02

2.071

1.005

4.268

0.048

Surgery

 No

Reference

   

Reference

   

 Yes

3.09

2.28

4.18

 < 0.001

1.614

1.082

2.41

0.019

Radiation

 No

Reference

       

 Yes

0.28

0.21

0.39

 < 0.001

    

Tumor size

  < 60 mm

Reference

       

 60–120 mm

1.9

1.29

2.8

 < 0.001

    

  > 120 mm

2.48

1.52

4.04

 < 0.001

    

 Unknown

1.07

0.76

1.52

0.7

    

Total number of tumors

 Single

Reference

       

 Multiple

0.28

0.21

0.38

 < 0.001

    
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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X