Table 1 Clinicopathological characteristics of patients with osteosarcoma
ALL N = 2157 | Chemotherapy N = 1887 | Non-chemotherapy N = 270 | p | |
|---|---|---|---|---|
Age | < 0.001 | |||
0–10 | 253 (11.7%) | 246 (13.0%) | 7 (2.59%) | |
11–20 | 955 (44.3%) | 933 (49.4%) | 22 (8.15%) | |
21–40 | 394 (18.3%) | 349 (18.5%) | 45 (16.7%) | |
41–60 | 323 (15.0%) | 244 (12.9%) | 79 (29.3%) | |
> 60 | 232 (10.8%) | 115 (6.09%) | 117 (43.3%) | |
Sex | 0.772 | |||
Male | 1212 (56.2%) | 1063 (56.3%) | 149 (55.2%) | |
Female | 945 (43.8%) | 824 (43.7%) | 121 (44.8%) | |
Race | 0.816 | |||
White | 1617 (75.0%) | 1413 (74.9%) | 204 (75.6%) | |
Black | 321 (14.9%) | 284 (15.1%) | 37 (13.7%) | |
Other | 219 (10.2%) | 190 (10.1%) | 29 (10.7%) | |
Marital | < 0.001 | |||
Married | 503 (23.3%) | 378 (20.0%) | 125 (46.3%) | |
Single | 1501 (69.6%) | 1423 (75.4%) | 78 (28.9%) | |
Divorced, separated, widowed, unmarried or domestic partner or unknown | 153 (7.09%) | 86 (4.56%) | 67 (24.8%) | |
Year of diagnosis1 | 0.619 | |||
2000–2002 | 571 (26.5%) | 490 (26.0%) | 81 (30.0%) | |
2003–2005 | 405 (18.8%) | 358 (19.0%) | 47 (17.4%) | |
2006–2008 | 447 (20.7%) | 391 (20.7%) | 56 (20.7%) | |
2009–2011 | 435 (20.2%) | 387 (20.5%) | 48 (17.8%) | |
2012–2014 | 299 (13.9%) | 261 (13.8%) | 38 (14.1%) | |
Median household income | 0.635 | |||
> $74,999 | 556 (25.8%) | 480 (25.4%) | 76 (28.1%) | |
$60,000– $74,999 | 982 (45.5%) | 863 (45.7%) | 119 (44.1%) | |
< $60,000 | 619 (28.7%) | 544 (28.8%) | 75 (27.8%) | |
Rural and urban | 0.401 | |||
Counties in metropolitan areas ge 1 million pop | 1356 (62.9%) | 1193 (63.2%) | 163 (60.4%) | |
Other | 801 (37.1%) | 694 (36.8%) | 107 (39.6%) | |
Primary site | < 0.001 | |||
Limbs | 1679 (77.8%) | 1549 (82.1%) | 130 (48.1%) | |
Pelvic bones, sacrum, coccyx and associated joints | 176 (8.16%) | 133 (7.05%) | 43 (15.9%) | |
Bones of skull and face and associated joints/Mandible | 191 (8.85%) | 131 (6.94%) | 60 (22.2%) | |
Vertebral column/Rib, sternum, clavicle and associated joints | 98 (4.54%) | 67 (3.55%) | 31 (11.5%) | |
Unknown | 13 (0.60%) | 7 (0.37%) | 6 (2.22%) | |
Laterality | < 0.001 | |||
Left | 940 (43.6%) | 849 (45.0%) | 91 (33.7%) | |
Right | 958 (44.4%) | 864 (45.8%) | 94 (34.8%) | |
Not a paired site or unknown | 259 (12.0%) | 174 (9.22%) | 85 (31.5%) | |
T | < 0.001 | |||
T1 | 556 (25.8%) | 485 (25.7%) | 71 (26.3%) | |
T2 | 770 (35.7%) | 705 (37.4%) | 65 (24.1%) | |
T3 | 53 (2.46%) | 46 (2.44%) | 7 (2.59%) | |
TX | 778 (36.1%) | 651 (34.5%) | 127 (47.0%) | |
N | 0.001 | |||
N0 | 1459 (67.6%) | 1304 (69.1%) | 155 (57.4%) | |
N1 | 39 (1.81%) | 34 (1.80%) | 5 (1.85%) | |
NX | 659 (30.6%) | 549 (29.1%) | 110 (40.7%) | |
M | 0.045 | |||
M0 | 1237 (57.3%) | 1096 (58.1%) | 141 (52.2%) | |
M1 | 322 (14.9%) | 285 (15.1%) | 37 (13.7%) | |
MX | 598 (27.7%) | 506 (26.8%) | 92 (34.1%) | |
Surgery | < 0.001 | |||
No | 284 (13.2%) | 209 (11.1%) | 75 (27.8%) | |
Yes | 1873 (86.8%) | 1678 (88.9%) | 195 (72.2%) | |
Radiation | < 0.001 | |||
No | 1940 (89.9%) | 1734 (91.9%) | 206 (76.3%) | |
Yes | 217 (10.1%) | 153 (8.11%) | 64 (23.7%) | |
Tumor size | < 0.001 | |||
< 60 mm | 330 (15.3%) | 275 (14.6%) | 55 (20.4%) | |
60–120 mm | 683 (31.7%) | 618 (32.8%) | 65 (24.1%) | |
> 120 mm | 362 (16.8%) | 335 (17.8%) | 27 (10.0%) | |
Unknown | 782 (36.3%) | 659 (34.9%) | 123 (45.6%) | |
Total number of in tumors | < 0.001 | |||
Single | 1825 (84.6%) | 1647 (87.3%) | 178 (65.9%) | |
Multiple | 332 (15.4%) | 240 (12.7%) | 92 (34.1%) | |
Survival months | 85.3 (70.9) | 90.1 (70.9) | 52.4 (61.5) | < 0.001 |
Status | < 0.001 | |||
Dead | 1123 (52.1%) | 915 (48.5%) | 208 (77.0%) | |
Alive | 1034 (47.9%) | 972 (51.5%) | 62 (23.0%) |