Fig. 3

Effect of Klotho pretreatment on hPDLSC immune-regulatory ability at the transplantation site. A M1 macrophages (iNOS positive cells) and M2 macrophages (Arg1 positive cells), and the number of iNOS and Arg1 positive cells in the bone tissue of each group. B Expression levels of inflammatory factors (IL-6, IL-1β and IL-10) in the bone tissues of the rats in each group, and the percent of positive area of each group; Scale bar = 50 µm (A) and 100 µm (B). *P < 0.05, **P < 0.01