LRP5-/6 gene polymorphisms and its association with risk of abnormal bone mass in postmenopausal women

Table 7 MDR analysis of the interaction of LRP5 gene rs41494349, rs2306862 and LRP6 gene rs10743980, rs2302685 alleles with the subjects’ age

Gene-age interaction		Training balancing accuracy	Testing accuracy	OR (95% CI)	P-value	Cross-validation consistency
1	rs2306862&Age	0.582	0.541	1.010 (1.003,1.017)	0.004**	9/10
	rs2302685& Age	0.621	0.597	1.016 (1.004,1.028)	0.011*	10/10
2	rs2306862&rs10743980& Age	0.551	0.745	1.008 (0.999,1.016)	0.082	8/10
3	rs41494349&rs2302685&rs10743980& Age	0.574	0.561	1.005 (1.002,1.008)	0.001**	10/10

SNP single-nucleotide polymorphism, OR odds ratio, 95% CI 95% confidence interval
Adjusted for menopausal years, *P < 0.05, **P < 0.01
Italicized value is statistically significant, *P < 0.05, **P < 0.01indicates statistical significance

ISSN: 1749-799X