Table 3 Binary logistic regression analysis of LRP5 and LRP6 SNP genotype and ABM susceptibility
Group | Genotype | OR (95% CI) | P-value | |
|---|---|---|---|---|
ABM | Control | |||
LRP5-rs41494349 | ||||
AA | 138(83.13) | 92(86.79) | 1 | 1.00 |
AG | 26(15.66) | 12(11.32) | 1.444(0.512,4.074) | 0.487 |
GG | 2(1.20) | 2(1.87) | 0.667(0.041,10.928) | 0.776 |
AG/GG | 28(16.87) | 14(13.21) | 1.333(0.500,3.556) | 0.565 |
Allele G | 30(9.04) | 16(7.55) | ||
LRP5-rs2306862 | ||||
CC | 108(65.06) | 86(81.13) | 1 | 1.00 |
CT | 50(30.12) | 16(15.09) | 2.353(1.039,6.186) | 0.041* |
TT | 8(4.82) | 4(3.77) | 2.028 (0.375,10.975) | 0.412 |
CT/TT | 28(43.37) | 10(18.87) | 2.434(1.071,5.531) | 0.034* |
Allele T | 66(24.10) | 24(11.32) | ||
LRP6-rs10743980 | ||||
CC | 94(56.63) | 70(66.04) | 1 | 1.00 |
CT | 64(38.55) | 32(30.19) | 1.489(0.709,3.130) | 0.293 |
TT | 8(4.82) | 4(3.77) | 1.489(0.258,8.595) | 0.656 |
CT/TT | 72(43.37) | 36(33.96) | 1.489(0.728,3.045) | 0.275 |
Allele T | 80(24.10) | 40(18.87) | ||
LRP6-rs2302685 | ||||
TT | 122(73.49) | 90(84.91) | 1 | 1.000 |
TC | 38(22.89) | 10(9.43) | 2.951(1.030,8.457) | 0.044* |
CC | 6(3.61) | 6(3.77) | 0.492(0.079,3.068) | 0.492 |
TC/CC | 40(26.51) | 16(15.09) | 2.319(0.911,5.898) | 0.078 |
Allele C | 50(15.06) | 22(10.38) | ||