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Fig. 3 | Journal of Orthopaedic Surgery and Research

Fig. 3

From: LncRNA ZFAS1 protects chondrocytes from IL-1β-induced apoptosis and extracellular matrix degradation via regulating miR-7-5p/FLRT2 axis

Fig. 3

Knockdown of ZFAS1 promoted the apoptosis and ECM degradation in IL-1β-treated chondrocytes. A The expression of ZFAS1 was detected in chondrocytes treated with sh-NC or knockdown of ZFAS1 by sh-ZFAS1#1-3 or without any treatment. **P < 0.01 compared with the sh-NC group. B The effects of knockdown of ZFAS1 on the cell viability of IL-1β-treated chondrocytes. *P < 0.05, **P < 0.01. C The effects of knockdown of ZFAS1 on the apoptosis rate of IL-1β-treated chondrocytes. **P < 0.01, compared with control group; ##P < 0.01, compared with IL-1β group. D Relative expression levels of MMP13, ADAMTS5, Collagen II, and Aggrecan measured by western blot analysis. *P < 0.05, **P < 0.01, compared with control group; #P < 0.05, ##P < 0.01, compared with IL-1β group

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X