Fig. 2

Changes in general status and serum inflammation marker throughout the experimental period. A Changes in body temperature during the study. Mean body temperature of rats in each group was measured preoperatively (day 0) and on post-surgical days 4, 7 and 14 using electronic thermometer. n = 13. B Mean body weight of rats in each group was measured preoperatively (day 0) and on post-surgical days 4, 7 and 14. n = 13. C The serum levels of α1-AGP during the study (pre-surgery [day 0] and on post-surgical days 7 and 14) in each treatment group. n = 8. D Incision healing scores of each treatment group on post-surgical days 14. n = 13. CON: control (no antibiotics); SV: system vancomycin (88 mg/kg, intraperitoneal injection, half an hour pre-surgery); VP 0.5: intra-wound vancomycin powder, 44 mg/kg, once before the closure of incision intraoperatively; VP 1.0: intra-wound vancomycin powder, 88 mg/kg; VP 2.0: intra-wound vancomycin powder, 176 mg/kg. Data were compared by analysis of variance (ANOVA) test. **P < 0.01 (compared with CON group), ^##P < 0.01 (compared with SV group), ^ΔΔP < 0.01 (compared with VP0.5 group). ^□□P < 0.01 (compared with VP1.0 group)