Table 1 24 markers of liver metabolomics in YGJ-balanced GIOP mice
No | Metabolites | log2(FC) | P-value | VIP | KEGG | HMDB | Change |
|---|---|---|---|---|---|---|---|
1 | Hydrocortisone | − 0.95252 | 0.00005 | 2.69217 | C00735 | HMDB0014879 | ↓ |
2 | S-Lactoylglutathione | 0.81368 | 0.00011 | 2.35069 | C03451 | HMDB0001066 | ↑ |
3 | Glucose-1-phosphate | 1.45230 | 0.00110 | 2.38254 | C00103 | HMDB0001586 | ↑ |
4 | 2-Hydroxy-2-methylbutanoic acid | − 0.88685 | 0.00175 | 2.22642 | – | HMDB0001987 | ↓ |
5 | 3-Hydroxybutyric acid | − 1.41490 | 0.00213 | 2.06207 | C01089 | HMDB0000357 | ↓ |
6 | L-cysteine | 0.85630 | 0.00255 | 2.31758 | C00097 | HMDB0000574 | ↑ |
7 | Glycerol-3-phosphate | 0.68772 | 0.00263 | 2.12763 | C00093 | HMDB0000126 | ↑ |
8 | 12-Hydroxydodecanoic acid | − 1.33550 | 0.00427 | 1.96774 | C08317 | HMDB0002059 | ↓ |
9 | Reduced nicotinamide adenine dinucleotide | 1.13700 | 0.00450 | 2.03607 | C00004 | HMDB0001487 | ↑ |
10 | Taurine | − 0.63548 | 0.00514 | 1.93328 | C00245 | HMDB0000251 | ↓ |
11 | Adenylosuccinic acid | 1.53770 | 0.00550 | 1.91842 | C03794 | HMDB0000536 | ↑ |
12 | Cys-Gly | 0.67538 | 0.00700 | 2.15769 | C01419 | HMDB0000078 | ↑ |
13 | Pentadecanoic acid | − 0.52265 | 0.00758 | 1.86792 | C16537 | HMDB0000826 | ↓ |
14 | GMP | 1.02350 | 0.01049 | 1.83988 | C00144 | – | ↑ |
15 | N-Methylhydantoin | − 0.81675 | 0.01147 | 2.06094 | C02565 | HMDB0003646 | ↓ |
16 | cGMP | − 2.13940 | 0.01447 | 1.81362 | C00942 | HMDB0001314 | ↓ |
17 | D-Sedoheptulose-7-phosphate | − 0.67165 | 0.01884 | 1.78553 | C05382 | HMDB0001068 | ↓ |
18 | Trans-2-Butene-1,4-dicarboxylic acid | 0.92075 | 0.01888 | 1.94288 | – | HMDB0000393 | ↑ |
19 | Dehydrocholic acid | − 0.42477 | 0.02335 | 1.97122 | C13154 | – | ↓ |
20 | Esculin | 0.62726 | 0.02685 | 1.63272 | C09264 | HMDB0030820 | ↑ |
21 | Uric acid | 0.42277 | 0.02799 | 1.62877 | C00366 | HMDB0000289 | ↑ |
22 | 4-Methoxycinnamic acid | 0.56239 | 0.02934 | 1.85603 | – | HMDB0002040 | ↑ |
23 | Glycoursodeoxycholic acid | − 0.61274 | 0.03382 | 1.58249 | – | HMDB0000708 | ↓ |
24 | Gamma-Glu-Leu | 0.73205 | 0.03719 | 1.76303 | – | HMDB0011171 | ↑ |