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Table 2 Information of 21 hub targets

From: Network pharmacology-based mechanism prediction and pharmacological validation of Bushenhuoxue formula attenuating postmenopausal osteoporosis in ovariectomized mice

Uniprot ID

Gene symbol

Description

P31749

AKT1

RAC-alpha serine/threonine-protein kinase

P15692

VEGFA

Vascular endothelial growth factor A

P01375

TNF

Tumor necrosis factor

P27361

MAPK3

Mitogen-activated protein kinase 3

P14780

MMP9

Matrix metalloproteinase-9

P04637

TP53

Cellular tumor antigen p53

P05412

JUN

Transcription factor AP-1

P01133

EGF

Pro-epidermal growth factor

P35354

PTGS2

Prostaglandin G/H synthase 2

P40763

STAT3

Signal transducer and activator of transcription 3

P05121

SERPINE1

Plasminogen activator inhibitor 1

P22301

IL10

Interleukin-10

P01584

IL1B

Interleukin-1 beta

P10145

CXCL8

Interleukin-8

P35222

CTNNB1

Catenin beta-1

P37231

PPARG

Peroxisome proliferator-activated receptor gamma

P01100

FOS

Proto-oncogene c-Fos

Q15848

ADIPOQ

Adiponectin

P03372

ESR1

Estrogen receptor

P02741

CRP

C-reactive protein

P28482

MAPK1

Mitogen-activated protein kinase 1