Fig. 5

Anti-osteosarcoma effects of PIP, DOX, and PIP + DOX in vivo using mice models. Balb/c mice were randomly grouped and injected intraperitoneally with saline, PIP (30 mg/kg), DOX (3 mg/kg), and PIP + DOX (30 mg/ kg and 3 mg/kg, respectively) for 18 days. A Images of various groups of tumours. B Variations in body weight of mice in different groups per three days after administration. C Tumour volume measured every three days. D Tumour weight in each group after isolation. E AST and BUN in serum for each group. *P < 0.05, **P < 0.01, ***P < 0.001