Fig. 3From: Piperine improves the sensitivity of osteosarcoma cells to doxorubicin by inducing apoptosis and inhibiting the PI3K/AKT/GSK-3β pathwayPIP combined with DOX promote apoptosis in osteosarcoma cells. A U2OS and 143B cells were treated with PIP, DOX, and PIP + DOX for 48 h. Apoptosis was determined using the Annexin V-FITC Flow Cytometry. B Quantification of apoptotic cells. *P < 0.05, **P < 0.01, ***P < 0.001Back to article page