The association between ADAM12 gene polymorphisms and osteoarthritis: an updated meta-analysis

Table 4 FPRP analysis of the noteworthy results for ADAM12 polymorphisms

SNP	Subgroup	Genetic model		OR	95% CI (P-value)	P	Power	Prior probability
SNP	Subgroup	Genetic model		OR	95% CI (P-value)	P	Power	0.25	0.1	0.01	0.001	0.0001
ADAM12
Rs1871054	Overall		Dominant model	1.26	1.05–1.51	0.013	0.970	0.037	0.103	0.557	0.927	0.992
			Recessive model	1.68	1.13–2.51	0.011	0.290	0.105	0.260	0.794	0.975	0.997
			Allelic model	1.34	1.05–1.71	0.019	0.818	0.064	0.170	0.693	0.958	0.995
			CC versus GG	1.62	1.05–2.50	0.031	0.364	0.195	0.420	0.889	0.988	0.999
	Asian		Dominant model	1.52	1.20–1.92	0.001	0.456	0.003	0.009	0.088	0.493	0.907
			Recessive model	2.08	1.35–3.20	0.001	0.068	0.036	0.102	0.555	0.926	0.992
			Allelic model	1.61	1.25–2.08	0.001	0.294	0.003	0.008	0.083	0.477	0.901
			CC versus GG	2.21	1.52–3.22	< 0.001	0.022	0.005	0.015	0.142	0.625	0.943
	Age < 60		Dominant model	1.31	1.02–1.68	0.033	0.857	0.105	0.260	0.794	0.975	0.997
			Recessive model	1.91	1.07–3.40	0.029	0.206	0.289	0.549	0.931	0.993	0.999
			Allelic model	1.39	1.01–1.92	0.286	0.678	0.168	0.378	0.870	0.985	0.999
			CC versus GG	1.74	1.00–3.02	0.049	0.299	0.330	0.596	0.942	0.994	0.999

Statistical significance values are shown in bold
CI Confidence interval; OR Odds ratio; FPRP values < 0.2 were considered significant

ISSN: 1749-799X