Table 3 The results were summarized in the meta-analysis of ADAM12 gene polymorphisms in association with knee osteoarthritis risk
From: The association between ADAM12 gene polymorphisms and osteoarthritis: an updated meta-analysis
Subgroup | Genetic model | Sample size | Test of association | Test of heterogeneity | Test of publication bias (Begg’s test) | Test of publication bias (Egger’s test) | ||||
|---|---|---|---|---|---|---|---|---|---|---|
Case/control | OR | 95% CI (P-value) | I2 (%) | P | Z | P | T | P | ||
Rs3740199 | ||||||||||
Overall | Dominant model | 1686/2845 | 0.98 | 0.86–1.13 (0.798) | 0 | 0.585 | 0.87 | 0.386 | − 0.75 | 0.479 |
Recessive model | 1686/2845 | 1.02 | 0.88–1.18 (0.778) | 43.0 | 0.092 | 0.12 | 0.902 | 0.05 | 0.960 | |
Allelic model | 2467/4030 | 0.98 | 0.91–1.05 (0.567) | 28.4 | 0.174 | 0.16 | 0.876 | − 0.21 | 0.841 | |
CC versus GG | 1686/2845 | 1.01 | 0.85–1.21 (0.884) | 22.8 | 0.248 | 0.87 | 0.386 | − 0.32 | 0.761 | |
GC versus GG | 1686/2845 | 0.97 | 0.84–1.12 (0.664) | 0 | 0.535 | 0.87 | 0.386 | − 0.86 | 0.424 | |
Subgroup | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 European | Dominant model | 313/365 | 0.74 | 0.49–1.11 (0.149) | 0 | 0.677 | 1.04 | 0.296 | 2.68 | 0.232 |
Recessive model | 313/365 | 0.86 | 0.61–1.20 (0.374) | 64.2 | 0.061 | 0.00 | 1.000 | − 1.27 | 0.424 | |
Allelic model | 1094/1550 | 0.91 | 0.82–1.02 (0.111) | 37.8 | 0.154 | 0.00 | 1.000 | 0.12 | 0.908 | |
CC versus GG | 313/365 | 0.67 | 0.41–1.10 (0.115) | 0 | 0.451 | 0.00 | 1.000 | 3.19 | 0.193 | |
GC versus GG | 313/365 | 0.79 | 0.51–1.21 (0.275) | 0 | 0.513 | 1.04 | 0.296 | 0.56 | 0.673 | |
 Asian | Dominant model | 1241/2316 | 1.04 | 0.85–1.25 (0.656) | 0 | 0.502 | 1.02 | 0.308 | 0.01 | 0.995 |
Recessive model | 1241/2316 | 1.02 | 0.86–1.21 (0.843) | 0 | 0.642 | 1.02 | 0.308 | − 0.03 | 0.978 | |
Allelic model | 1241/2316 | 1.02 | 0.92–1.13 (0.689) | 0 | 0.398 | 1.02 | 0.308 | − 0.01 | 0.991 | |
CC versus GG | 1241/2316 | 1.04 | 0.85–1.27 (0.703) | 0.4 | 0.390 | 1.02 | 0.308 | − 0.01 | 0.995 | |
GC versus GG | 1241/2316 | 1.04 | 0.88–1.22 (0.681) | 0 | 0.709 | 1.02 | 0.308 | − 0.01 | 0.990 | |
 Male | Dominant model | 211/942 | 1.16 | 0.75–1.80 (0.494) | 0 | 0.766 | 0.00 | 1.000 | 0.49 | 0.709 |
Recessive model | 211/942 | 1.07 | 0.74–1.53 (0.735) | 69.1 | 0.039 | 0.00 | 1.000 | 0.74 | 0.593 | |
Allelic model | 211/942 | 1.15 | 0.93–1.43 (0.201) | 68.9 | 0.040 | 0.00 | 1.000 | 0.60 | 0.656 | |
CC versus GG | 211/942 | 1.25 | 0.79–1.97 (0.340) | 49.2 | 0.140 | 1.04 | 0.296 | 0.67 | 0.623 | |
GC versus GG | 211/942 | 1.11 | 0.78–1.58 (0.565) | 65.2 | 0.057 | 0.00 | 1.000 | 0.27 | 0.832 | |
 Female | Dominant model | 677/1010 | 1.38 | 1.02–1.86 (0.037) | 36.1 | 0.209 | 1.04 | 0.296 | − 0.56 | 0.675 |
Recessive model | 677/1010 | 0.98 | 0.77–1.23 (0.843) | 3.6 | 0.354 | 1.04 | 0.296 | − 0.96 | 0.513 | |
Allelic model | 677/1010 | 0.96 | 0.84–1.11 (0.590) | 0 | 0.629 | 0.00 | 1.000 | − 0.36 | 0.777 | |
CC versus GG | 677/1010 | 0.91 | 0.68–1.22 (0.534) | 0 | 0.404 | 1.04 | 0.296 | − 1.13 | 0.461 | |
GC versus GG | 677/1010 | 1.00 | 0.83–1.20 (0.969) | 0 | 0.869 | 0.00 | 1.000 | − 0.27 | 0.833 | |
 Age < 60 | Dominant model | 163/215 | 0.94 | 0.47–1.90 (0.864) | 0 | 0.713 | 0.00 | 1.000 | No | No |
Recessive model | 163/215 | 1.00 | 0.67–1.51 (0.988) | 64.2 | 0.039 | 0.00 | 1.000 | No | No | |
Allelic model | 163/215 | 1.09 | 0.79–1.51 (0.587) | 73.0 | 0.054 | 0.00 | 1.000 | No | No | |
CC versus GG | 163/215 | 0.95 | 0.45–1.99 (0.891) | 0 | 0.809 | 0.00 | 1.000 | No | No | |
GC versus GG | 163/215 | 0.93 | 0.45–1.93 (0.840) | 6.6 | 0.301 | 0.00 | 1.000 | No | No | |
 Age ≥ 60 | Dominant model | 1523/2630 | 0.98 | 0.86–1.13 (0.821) | 8.6 | 0.362 | 1.88 | 0.060 | − 0.79 | 0.475 |
Recessive model | 1523/2630 | 1.02 | 0.87–1.20 (0.813) | 31.9 | 0.184 | 0.38 | 0.707 | 0.12 | 0.909 | |
Allelic model | 2304/3815 | 0.97 | 0.90–1.05 (0.476) | 18.4 | 0.279 | 0.73 | 0.466 | − 0.69 | 0.510 | |
CC versus GG | 1523/2630 | 1.02 | 0.85–1.22 (0.853) | 44.3 | 0.110 | 1.13 | 0.260 | − 0.23 | 0.828 | |
GC versus GG | 1523/2630 | 0.97 | 0.83–1.13 (0.688) | 0 | 0.421 | 1.50 | 0.133 | − 1.03 | 0.360 | |
Rs1871054 | ||||||||||
Overall | Dominant model | 1204/1425 | 1.26 | 1.05–1.51 (0.013) | 24.8 | 0.223 | 0.10 | 0.917 | − 0.17 | 0.869 |
Recessive model | 1204/1425 | 1.68 | 1.13–2.51 (0.011) | 77.4 | < 0.001 | − 0.10 | 1.000 | 0.79 | 0.458 | |
Allelic model | 1204/1425 | 1.34 | 1.05–1.71 (0.019) | 76.4 | < 0.001 | 0.10 | 0.917 | 0.53 | 0.610 | |
CC versus TT | 1204/1425 | 1.62 | 1.05–2.50 (0.031) | 69.1 | 0.001 | 0.31 | 0.754 | 0.34 | 0.743 | |
TC versus TT | 1204/1425 | 1.07 | 0.88–1.30 (0.506) | 0 | 0.907 | 0.31 | 0.754 | − 1.86 | 0.106 | |
Subgroup | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 European | Dominant model | 346/428 | 1.05 | 0.76–1.45 (0.787) | 0 | 0.660 | 0.73 | 0.462 | 3.94 | 0.029 |
Recessive model | 346/428 | 1.85 | 0.94–3.63 (0.075) | 72.5 | 0.006 | 1.71 | 0.086 | 3.78 | 0.032 | |
Allelic model | 346/428 | 1.33 | 0.91–1.95 (0.145) | 66.0 | 0.019 | 1.22 | 0.221 | 4.29 | 0.023 | |
CC versus TT | 346/428 | 1.56 | 0.81–3.01 (0.187) | 55.4 | 0.062 | 0.73 | 0.462 | 3.68 | 0.035 | |
TC versus TT | 346/428 | 0.92 | 0.65–1.31 (0.63) | 0 | 0.999 | 0.24 | 0.806 | 0.43 | 0.697 | |
 Asian | Dominant model | 726/779 | 1.52 | 1.20–1.92 (0.001) | 0 | 0.773 | 1.04 | 0.296 | 8.36 | 0.076 |
Recessive model | 726/779 | 2.08 | 1.35–3.20 (0.001) | 70.3 | 0.034 | 0.00 | 1.000 | 6.03 | 0.105 | |
Allelic model | 726/779 | 1.61 | 1.25–2.08 (< 0.001) | 65.6 | 0.055 | 0.00 | 1.000 | 13.38 | 0.047 | |
CC versus TT | 726/779 | 2.21 | 1.52–3.22 (< 0.001) | 38.1 | 0.199 | 0.00 | 1.000 | 13.63 | 0.047 | |
TC versus TT | 726/779 | 1.22 | 0.95–1.57 (0.125) | 0 | 0.836 | 0.00 | 1.000 | − 2.07 | 0.287 | |
 Male | Dominant model | 138/160 | 1.16 | 0.75–1.80 (0.494) | 0 | 0.766 | 1.71 | 0.086 | 1.91 | 0.152 |
Recessive model | 138/160 | 2.32 | 1.01–5.35 (0.049) | 63.1 | 0.029 | − 0.24 | 1.000 | 1.00 | 0.390 | |
Allelic model | 138/160 | 1.52 | 0.95–2.43 (0.080) | 57.2 | 0.053 | 0.73 | 0.462 | 1.57 | 0.215 | |
CC versus TT | 138/160 | 2.02 | 0.91–4.47 (0.085) | 39.6 | 0.157 | − 0.24 | 1.000 | 1.43 | 0.248 | |
TC versus TT | 138/160 | 0.93 | 0.57–1.51 (0.767) | 0 | 0.992 | − 0.24 | 1.000 | 0.42 | 0.702 | |
 Female | Dominant model | 435/455 | 1.38 | 1.02–1.86 (0.037) | 36.1 | 0.209 | 1.04 | 0.296 | − 2.94 | 0.210 |
Recessive model | 435/455 | 1.38 | 1.01–1.88 (0.042) | 0 | 0.448 | 1.04 | 0.296 | − 1.49 | 0.376 | |
Allelic model | 435/455 | 1.20 | 0.90–1.60 (0.220) | 42.7 | 0.174 | 1.04 | 0.296 | − 2.22 | 0.270 | |
CC versus TT | 435/455 | 1.43 | 0.82–2.50 (0.211) | 60.8 | 0.003 | 1.04 | 0.296 | − 2.10 | 0.283 | |
TC versus TT | 435/455 | 1.27 | 0.92–1.75 (0.143) | 5.0 | 0.349 | 1.04 | 0.296 | − 4.05 | 0.154 | |
 Age < 60 | Dominant model | 211/942 | 1.31 | 1.02–1.68 (0.033) | 0 | 0.562 | 0.24 | 0.806 | 0.09 | 0.930 |
Recessive model | 211/942 | 1.91 | 1.07–3.40 (0.029) | 68.7 | 0.012 | 1.22 | 0.221 | 1.40 | 0.255 | |
Allelic model | 211/942 | 1.39 | 1.01–1.92 (0.286) | 61.4 | 0.035 | 0.73 | 0.462 | 0.85 | 0.459 | |
CC versus GG | 211/942 | 1.74 | 1.00–3.02 (0.049) | 48.5 | 0.100 | 0.24 | 0.806 | 0.85 | 0.470 | |
GC versus GG | 211/942 | 1.16 | 0.89–1.51 (0.285) | 0 | 0.835 | 0.24 | 0.806 | − 1.78 | 0.173 | |
 Age ≥ 60 | Dominant model | 677/1010 | 1.20 | 0.92–1.57 (0.172) | 59.9 | 0.058 | − 0.34 | 1.000 | − 1.03 | 0.413 |
Recessive model | 677/1010 | 1.49 | 0.77–2.89 (0.241) | 86.7 | < 0.001 | 1.70 | 0.089 | − 4.09 | 0.055 | |
Allelic model | 677/1010 | 1.27 | 0.82–1.97 (0.286) | 87.3 | < 0.001 | 1.70 | 0.089 | − 2.65 | 0.118 | |
CC versus GG | 677/1010 | 1.45 | 0.67–3.14 (0.349) | 83.5 | < 0.001 | 1.70 | 0.089 | − 2.14 | 0.166 | |
GC versus GG | 677/1010 | 0.97 | 0.73–1.30 (0.854) | 0 | 0.749 | − 0.34 | 1.000 | − 1.02 | 0.415 | |
Rs1278279 | ||||||||||
Overall | Dominant model | 316/379 | 1.19 | 0.88–1.61 (0.265) | 0 | 0.950 | 0.00 | 1.000 | No | No |
Recessive model | 316/379 | 0.80 | 0.44–1.47 (0.474) | 0 | 0.995 | 0.00 | 1.000 | No | No | |
Allelic model | 316/379 | 1.02 | 0.80–1.30 (0.893) | 0 | 0.962 | 0.00 | 1.000 | No | No | |
AA versus GG | 316/379 | 0.88 | 0.47–1.62 (0.671) | 0 | 0.995 | 0.00 | 1.000 | No | No | |
GA versus GG | 316/379 | 1.26 | 0.91–1.73 (0.158) | 0 | 0.935 | 0.00 | 1.000 | No | No | |
Rs1044122 | ||||||||||
Overall | Dominant model | 904/988 | 1.15 | 0.77–1.72 (0.479) | 76.0 | 0.006 | − 0.34 | 1.000 | − 3.17 | 0.087 |
Recessive model | 904/988 | 0.87 | 0.49–1.54 (0.634) | 76.4 | 0.005 | 1.02 | 0.308 | − 6.22 | 0.025 | |
Allelic model | 904/988 | 1.20 | 0.81–1.79 (0.359) | 88.1 | < 0.001 | 0.00 | 1.000 | − 0.77 | 0.520 | |
CC versus TT | 904/988 | 0.96 | 0.48–1.93 (0.877) | 81.9 | 0.001 | 1.02 | 0.308 | − 4.92 | 0.039 | |
TC versus TT | 904/988 | 1.24 | 0.91–1.68 (0.179) | 55.8 | 0.079 | − 0.34 | 1.000 | − 4.64 | 0.044 | |
Subgroup | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 Male | Dominant model | 142/166 | 1.31 | 0.83–2.05 (0.248) | 0 | 0.843 | 0.00 | 1.000 | No | No |
Recessive model | 142/166 | 0.98 | 0.47–2.05 (0.962) | 0 | 0.404 | 0.00 | 1.000 | No | No | |
Allelic model | 142/166 | 1.16 | 0.82–1.63 (0.398) | 0 | 0.549 | 0.00 | 1.000 | No | No | |
CC versus TT | 142/166 | 1.15 | 0.53–2.48 (0.727) | 0 | 0.459 | 0.00 | 1.000 | No | No | |
TC versus TT | 142/166 | 1.35 | 0.84–2.17 (0.222) | 0 | 0.934 | 0.00 | 1.000 | No | No | |
 Female | Dominant model | 446/443 | 1.25 | 0.46–3.38 (0.658) | 91.5 | 0.001 | 0.00 | 1.000 | No | No |
Recessive model | 446/443 | 0.79 | 0.15–4.26 (0.782) | 91.6 | 0.001 | 0.00 | 1.000 | No | No | |
Allelic model | 446/443 | 1.09 | 0.43–2.75 (0.852) | 94.6 | < 0.001 | 0.00 | 1.000 | No | No | |
CC versus TT | 446/443 | 0.89 | 0.12–6.83 (0.909) | 93.6 | < 0.001 | 0.00 | 1.000 | No | No | |
TC versus TT | 446/443 | 1.35 | 0.64–2.87 (0.430) | 83.6 | 0.014 | 0.00 | 1.000 | No | No | |
 Age < 60 | Dominant model | 211/942 | 1.29 | 0.61–2.71 (0.509) | 89.2 | 0.002 | 0.00 | 1.000 | No | No |
Recessive model | 211/942 | 0.88 | 0.22–3.40 (0.835) | 91.5 | 0.001 | 0.00 | 1.000 | No | No | |
Allelic model | 211/942 | 1.12 | 0.54–2.33 (0.760) | 93.8 | < 0.001 | 0.00 | 1.000 | No | No | |
CC versus GG | 211/942 | 0.99 | 0.20–4.96 (0.991) | 93.2 | < 0.001 | 0.00 | 1.000 | No | No | |
GC versus GG | 211/942 | 1.38 | 0.81–2.34 (0.238) | 76.5 | 0.039 | 0.00 | 1.000 | No | No | |
 Age ≥ 60 | Dominant model | 677/1010 | 1.01 | 0.73–1.39 (0.972) | 0 | 0.948 | 0.00 | 1.000 | No | No |
Recessive model | 677/1010 | 0.84 | 0.56–1.26 (0.394) | 0 | 0.767 | 0.00 | 1.000 | No | No | |
Allelic model | 677/1010 | 1.29 | 0.68–2.48 (0.432) | 88.9 | 0.003 | 0.00 | 1.000 | No | No | |
CC versus GG | 677/1010 | 0.87 | 0.56–1.37 (0.542) | 0 | 0.803 | 0.00 | 1.000 | No | No | |
GC versus GG | 677/1010 | 1.05 | 0.75–1.48 (0.759) | 0 | 0.978 | 0.00 | 1.000 | No | No | |