The association between ADAM12 gene polymorphisms and osteoarthritis: an updated meta-analysis

Yang, Su; Wang, Yue-peng; Li, Xi-yong; Han, Peng-yong; Han, Peng-fei

doi:10.1186/s13018-023-03626-7

Journal of Orthopaedic Surgery and Research

Table 1 Characteristics of studies included in the meta-analysis of overall OA

From: The association between ADAM12 gene polymorphisms and osteoarthritis: an updated meta-analysis

Study author	Year	Country	Ethnicity	Sex	Number of samples			Age case/control (mean)	Genotyping method	Quality score
Study author	Year	Country	Ethnicity	Sex	Cases	Controls	Total	Age case/control (mean)	Genotyping method	Quality score
Kerna et al. (1) [37]	2009	Estonian	European	Male	40	60	100	32–55/NR	PCR–RFLP	8
Kerna et al. (1) [37]	2009	Estonian	European	Female	123	155	278	32–55/NR	PCR–RFLP	8
Rodriguez-Lopez et al. [40]	2009	Spain	European	Male	51	179	230	68 (55–84)/68 (55–94)	Multiplex PCR	6
		Spain	European	Female	211	115	326	68 (55–84)/68 (55–94)	Multiplex PCR	6
		UK	European	Male	164	342	506	65 (55–85)/69 (55–89)	Multiplex PCR	6
		UK	European	Female	196	356	552	65 (55–85)/69 (55–89)	Multiplex PCR	6
		Greece	European	Male	20	56	76	72 (62–85)/70 (46–88)	Multiplex PCR	6
		Greece	European	Female	139	137	276	72 (62–85)/70 (46–88)	Multiplex PCR	6
Valdes et al	2004	UK	European	Female	280	469	749	43–67/NR	PCR–SSCP	5
Shin et al. [38]	2012	Korean	Asian	Male	171	882	1053	67.4 ± 7.9/62.7 ± 7.9	TaqMan	7
Shin et al. [38]	2012	Korean	Asian	Female	554	855	1409	67.4 ± 7.9/62.7 ± 7.9	TaqMan	7
Kerna et al. (2) [26]	2013	Estonian	European	Male	54	66	120	44.35.9/46.1 (5.5)	TaqMan	8
Kerna et al. (2) [26]	2013	Estonian	European	Female	131	143	274	44.35.9/46.1 (5.5)	TaqMan	8
Lou et al. [39]	2014	China	Asian	Male	58	77	135	63.1 ± 5.2/62.2 ± 4.2	TaqMan	9
Lou et al. [39]	2014	China	Asian	Female	94	102	196	63.1 ± 5.2/62.2 ± 4.2	TaqMan	9
Wang et al. [25]	2015	China	Asian	Male	58	62	120	67.4 ± 4.2/65.9 ± 5.3	iMLDR	9
Wang et al. [25]	2015	China	Asian	Female	106	138	244	67.4 ± 4.2/65.9 ± 5.3	iMLDR	9
Poonpet et al. [41]	2016	Thai	Asian	Male	53	51	104	69.0 ± 8.2/57.3 ± 5.8	HRM-SNP	7
Poonpet et al. [41]	2016	Thai	Asian	Female	147	149	296	69.0 ± 8.2/57.3 ± 5.8	HRM-SNP	7
Aguilar et al. [42]	2020	Mexico	North America	Male	46	68	114	63.53 ± 14.52/55.98 ± 13.13	TaqMan	8
Aguilar et al. [42]	2020	Mexico	North America	Female	86	96	182	63.53 ± 14.52/55.98 ± 13.13	TaqMan	8
Haberal et al. [5]	2021	Turkish	European	Male	42	26	48	66 ± 9.8/57.3 ± 11.2	Real-time PCR	8
Haberal et al. [5]	2021	Turkish	European	Female	108	124	232	66 ± 9.8/57.3 ± 11.2	Real-time PCR	8
Fatima et al. [24]	2022	Pakistan	Asian	Male	88	100	188	50.45 ± 0.49/49.13 ± 0.53	ARMS‐PCR	8
Fatima et al. [24]	2022	Pakistan	Asian	Female	312	300	612	50.45 ± 0.49/49.13 ± 0.53	ARMS‐PCR	8

NR Not reported

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ISSN: 1749-799X

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