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Fig. 5 | Journal of Orthopaedic Surgery and Research

Fig. 5

From: DEPDC1 and KIF4A synergistically inhibit the malignant biological behavior of osteosarcoma cells through Hippo signaling pathway

Fig. 5

Upregulation of KIF4A partially reversed the effect of DEPDC1 interference on proliferation of OS cells. A/B The expression of KIF4A in U2OS cells transfected with Ov-KIF4A was detected by RT-qPCR and western blot. ***P < 0.001 versus Control group. ###P < 0.001 versus Ov-NC group. C The viability of U2OS cells transfected with sh-DEPDC1 and Ov-KIF4A was determined by CCK-8 assay. D The proliferation of U2OS cells transfected with si-DEPDC1 and Ov-KIF4A was observed by EdU staining. E The expression of PCNA in U2OS cells transfected with sh-DEPDC1 and Ov-KIF4A was detected by western blot. ***P < 0.001 versus Control group. ###P < 0.001 versus sh-NC group. +++P < 0.001 versus si-DEPDC1 + Ov-NC group

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X