Table 1 Basic characteristics of the included studies
Study | Intervention measures | N (Male/Female) | Age (years) | Weight (kg) | |||
|---|---|---|---|---|---|---|---|
TXA | CG | TXA | CG | TXA | CG | ||
Elwatidy et al. [14] | 30 mg/kg + 1 mg/(kg h) A + B | 32 (21/11) | 32 (18/14) | 51.56 + 19.08 | 49.75 + 21.04 | 72.48 ± 13.81 | 69.63 ± 17.29 |
Wong et al. [15] | 10 mg/kg + 1 mg/(kg h) A + B | 73 (21/52) | 74 (26/48) | 56.8 ± 16.2 | 50.0 ± 16.2 | 72.9 ± 17.2 | 73.9 ± 16.1 |
Liang et al. [16] | 2000 mg C | 30 (15/15) | 30 (14/16) | 51.13 ± 10.72 | 53.50 ± 10.26 | 26.2 ± 4.1 (BMI) | 25.3 ± 5.2 (BMI) |
Shi et al. [17] | 30 mg/kg + 2 mg/(kg h) A + B | 50 (25/25) | 46 (22/24) | 53.76 ± 12.06 | 55.87 ± 13.14 | 63.10 ± 10.82 | 62.13 ± 9.98 |
Nagabhushan et al. [3] | 10 mg/kg + 1 mg/(kg h) A + B | 25 (9/16) | 25 (11/14) | 49.60 ± 9.79 | 51.72 ± 9.71 | 58.84 ± 3.31 | 60.96 ± 7.35 |
Kim et al. [18] | 10 mg/kg + 2 mg/(kg h) A + B | 24 (12/12) | 24 (15/9) | 61.0 ± 9.0 | 65.2 ± 7.0 | 25.9 ± 3.2 (BMI) | 25.1 ± 3.2 (BMI) |
Wang et al. [19] | 10 mg/kg + 1 mg/(kg h) A + B | 39 (25/18) | 41 (18/19) | 41.2 ± 10.3 | 42.5 ± 9.5 | 63.2 ± 18.3 | 64.3 ± 19.1 |
Mu et al. [20] | 15 mg/kg A | 45 (27/18) | 42 (23/19) | 54.20 ± 7.37 | 52.57 ± 6.73 | 24.83 ± 1.95 (BMI) | 23.93 ± 1.35 (BMI) |
Ou et al. [21] | 15 mg/kg + 1 g A + C | 59 (30/29) | 59 (31/28) | 64.2 ± 4.6 | 64.0 ± 5.1 | 22.64 ± 3.29 (BMI) | 22.57 ± 3.20 (BMI) |
Sun et al. [22] | 15 mg/kg A | 26 (15/11) | 37 (22/15) | 57.12 ± 11.55 | 51.51 ± 13.57 | 24.86 ± 4.72 (BMI) | 24.44 ± 3.57 (BMI) |
Xu et al. [23] | 1 g C | 30 (13/17) | 30 (14/16) | 49.6 ± 12.8 | 50.6 ± 16.2 | 25.3 ± 3.0 (BMI) | 25.7 ± 3.0 (BMI) |
Zhang et al. [24] | 1 g + 1 g A + C | 151 (57/94) | 138 (47/91) | 54.73 ± 9.93 | 57.04 ± 10.20 | 25.82 ± 3.28 | 25.20 ± 3.54 |
Li et al. [25] | 2 g + 1 g A + C | 212 (74/138) | 227 (84/143) | 55.4 ± 10.61 | 55.26 ± 10.44 | 25.73 ± 3.31 (BMI) | 25.71 ± 3.63 (BMI) |
Yan et al. [26] | 20 mg/kg + 10 mg/(kg h) A + B | 40 (16/24) | 40 (22/18) | 53 ± 7 | 52 ± 8 | 25.4 ± 3.1 (BMI) | 24.4 ± 3.4 (BMI) |