Table 2 GO biological processes related to aging and inflammation
Keywords | GO_ID | GO_term | UP_GENE | DOWN_GENE | Gene_UP_list | Gene_DOWN_list | Rich_factor | P value |
|---|---|---|---|---|---|---|---|---|
Aging | GO:0007568 | Aging | 13 | 6 | FOXO4, SREBF1, ALDH3A1, JUND, PRNP, FADS1, ARG2, NFE2L2, CDKN1C, PTGS2, APOD, BCL6, EDNRB | EDN1, SERPINE1, IGFBP1, COMP, CLDN1, VCAM1 | 3.236 | 1.01E−05 |
Inflammat- | GO:0150077 | Regulation of neuroinflammatory response | 2 | 2 | PTGS2, NR1D1 | MMP3, IL6 | 4.370 | 6.03E−03 |
GO:0150076 | Neuroinflammatory response | 2 | 2 | NR1D1, PTGS2 | MMP3, IL6 | 4.088 | 7.87E−03 | |
GO:0002673 | Regulation of acute inflammatory response | 3 | 1 | EDNRB, PTGS2, ADORA1 | IL6 | 3.960 | 8.93E−03 | |
GO:0002526 | Acute inflammatory response | 3 | 2 | ADORA1, PTGS2, EDNRB | IL6, VCAM1 | 2.418 | 4.14E−02 | |
GO:0050729 | Positive regulation of inflammatory response | 2 | 4 | PTGS2, AGTR1 | SERPINE1, TGM2, WNT5A, IL6 | 2.223 | 4.41E−02 | |
GO:0006954 | Inflammatory response | 12 | 17 | BCL6, AGTR1, ADORA1, CDO1, EPHA2, LPCAT3, NR1D1, EDNRB, APOD, PTGS2, NFE2L2, CD14 | CXCL8, VCAM1, TGM2, CXCL6, BDKRB1, MMP3, SERPINE1, IL6, TSPAN2, CXCL5, TNFAIP3, WNT5A, NDST1, CYSLTR1, CCR1, CMKLR1, CXCL1 | 2.002 | 5.53E−04 | |
GO:0050727 | Regulation of inflammatory response | 7 | 6 | LPCAT3, PTGS2, ADORA1, AGTR1, BCL6, EDNRB, NR1D1 | SERPINE1, MMP3, IL6, TNFAIP3, TGM2, WNT5A | 1.911 | 2.20E−02 |