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Fig. 1 | Journal of Orthopaedic Surgery and Research

Fig. 1

From: LncRNA EBLN3P attributes methotrexate resistance in osteosarcoma cells through miR-200a-3p/O-GlcNAc transferase pathway

Fig. 1

Increased EBLN3P is related to methotrexate (MTX) resistance in osteosarcoma. A Expression of EBLN3P in osteosarcoma was significantly higher than adjacent tissues. B Patients with MTX resistance have higher EBLN3P expression than MTX-sensitive patients. C The IC50 of MTX in human osteosarcoma cell line MNNG/HOS, Saos-2, U2OS, and MG63. D The expression of LncRNA EBLN3P in each cell lines. E The positive correlation of MTX IC50 and RNA expression of EBLN3P in each cell lines. F and G The cell viability of the 2-cell line increased with the induction of MTX, which demonstrated by increased IC50 after induction. **p < 0.01

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X