Fig. 3
ASC-Exo promoted IL-1β-reduced cell proliferation and inhibited IL-1β-induced cell apoptosis of ATDC5 cells and in delivering miR-338-3p. A The cell proliferation of ATDC5 cells was tested by CCK-8 assay. B and C Flow cytometry analysis of apoptosis in ATDC5 cells. D The expression level of miR-338-3p in ASC-Exos (E and F) and ATDC5 cells (G) was determined by RT-qPCR. **P < 0.01 (VS. NC), ##P < 0.01 (VS. IL-1β), &P < 0.05 (VS. IL-1β + ASCs), &&P < 0.01 (VS. IL-1β + ASCs). ASCGW4869, ASCs treated with GW4869; ASC-NC−, ASCs treated with NC inhibitor; ASC-338−, ASCs treated with miR-338-3p inhibitor; ASC-NC+, ASCs treated with NC mimic; ASC-338+, ASCs treated with miR-338-3p mimic