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Table 2 Case–control comparison of the frequency of the genotype and allele for rs7607479 and rs6435818

From: Genetic variant in SPAG16 is associated with the susceptibility of ACPA-positive rheumatoid arthritis possibly via regulation of MMP-3

rs7607479 (C/T)

Genotype

p

Allele

p

Odds ratio (95% CIa)

CC

CT

TT

C

T

Patients (n = 500)

54 (10.8%)

201 (40.2%)

245 (49.0%)

0.005

309 (30.9%)

691 (69.1%)

0.001

0.77 (0.65–0.90)

Controls (n = 1000)

140 (14.0%)

456 (45.6%)

404 (40.4%)

 

736 (36.8%)

1264 (63.2%)

  

rs6435818 (A/C)

Genotype

p

Allele

p

Odds ratio (95% CIa)

AA

AC

CC

A

C

Patients (n = 500)

15 (3.0%)

153 (30.6%)

332 (66.4%)

0.41

183 (18.3%)

817 (81.7%)

0.35

0.91 (0.75–1.10)

Controls (n = 1000)

44 (4.4%)

308 (30.8%)

648 (64.8%)

 

396 (19.8%)

1604 (80.2%)

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