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Fig. 1 | Journal of Orthopaedic Surgery and Research

Fig. 1

From: Genetic variant in SPAG16 is associated with the susceptibility of ACPA-positive rheumatoid arthritis possibly via regulation of MMP-3

Fig. 1

Tissue expression of MMP-3 and SPAG16 in RA patients. a, b Significantly higher expression of MMP-3 was observed in RA tissues as compared with the non-RA controls. There was no significant difference regarding the tissue expression of SPAG16 between the two groups; c, d There was significant difference regarding MMP-3 expression among the three genotypes (p = 0.01). The mRNA expression of MMP-3 was 1.39-fold higher in patients with genotype TT than in the patients with genotype CC (post hoc p = 0.006). There was significant difference regarding MMP-3 expression between genotype CT and genotype TT (post hoc p = 0.002). There was no significant difference between genotype CT and genotype CC (post hoc p = 0.16). There was no significant difference regarding the tissue expression of SPAG16 among the three genotypes

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X