Fig. 2

Circ_0083964 downregulation impeded cell proliferation, invasion, migration and inflammatory response in RA-FLSs. A The level of circ_0083964 was examined by qRT-PCR in RA-FLSs transfected with si-NC or si-circ_0083964. B–H RA-FLSs were divided into 2 groups: si-NC and si-circ_0083964. (B-F) Cell viability (B), EdU-positive cells (C), apoptosis (D), invasion (E) and migration (F) in RA-FLSs were evaluated by MTT assay, EdU assay, flow cytometry, transwell assay and wound-healing assay, individually. G The protein expression of cleaved caspase-3 and MMP9 was investigated by western blot in RA-FLSs. H ELISA assay was employed to examine the concentrations of IL-6 and TNF-α in RA-FLSs. **P < 0.01, ***P < 0.001, ****P < 0.0001