Table 1 GO analysis of p16, p53, pcna, and co-expressed genes
From: Prognostic value of p16, p53, and pcna in sarcoma and an evaluation of immune infiltration
The enriched | GO-ID | Description | Count | P Value | Genes |
|---|---|---|---|---|---|
BP | 0,046,104 | Thymidine metabolic process | 2 | 0.00380782 | tk2, tk1 |
BP | 0,007,265 | Ras protein signal transduction | 3 | 0.007837465 | cdkn2a, tp53, mapkapk3 |
BP | 0,048,010 | Vascular endothelial growth factor receptor signaling pathway | 3 | 0.00827545 | nck2, ccl2, mapkapk3 |
BP | 0,009,157 | Deoxyribonucleoside monophosphate biosynthetic process | 2 | 0.009493227 | tk2, tk1 |
BP | 0,031,497 | Chromatin assembly | 2 | 0.015147194 | tp53, chaf1a |
BP | 0,043,065 | Positive regulation of apoptotic process | 4 | 0.019103663 | hip1r, cdkn2a, tp53, nr4a1 |
BP | 0,007,165 | Signal transduction | 7 | 0.020711051 | nck2, tle2, tyrobp, ccl2, gdf15, mapkapk3, nr4a1 |
BP | 0,016,925 | Protein sumoylation | 3 | 0.020834415 | cdkn2a, pcna, tp53 |
BP | 0,090,399 | Replicative senescence | 2 | 0.022637202 | cdkn2a, tp53 |
BP | 0,043,097 | Pyrimidine nucleoside salvage | 2 | 0.022637202 | tk2, tk1 |
BP | 0,009,165 | Nucleotide biosynthetic process | 2 | 0.028218465 | tk2, tk1 |
BP | 0,006,260 | DNA replication | 3 | 0.035043323 | pcna, rfc2, chaf1a |
BP | 0,042,276 | Error-prone translesion synthesis | 2 | 0.035612139 | pcna, rfc2 |
BP | 0,070,987 | Error-free translesion synthesis | 2 | 0.035612139 | pcna, rfc2 |
BP | 0,006,297 | Nucleotide-excision repair, DNA gap filling | 2 | 0.044777623 | pcna, rfc2 |
BP | 0,071,158 | Positive regulation of cell cycle arrest | 2 | 0.046600567 | cdkn2a, tp53 |
BP | 0,007,507 | Heart development | 3 | 0.047320182 | acan, pcna, cacna1c |
BP | 0,071,897 | DNA biosynthetic process | 2 | 0.04842014 | tk2, tk1 |
CC | 0,005,663 | DNA replication factor C complex | 2 | 0.010164404 | pcna, rfc2 |
CC | 0,016,605 | PML body | 3 | 0.012026098 | tp53, sp140, trim27 |
CC | 0,005,654 | Nucleoplasm | 11 | 0.013931808 | cdkn2a, tle2, flii, pcna, tp53, rfc2, sp140, trim27, mapkapk3, nr4a1, hist2h4a |
CC | 0,005,657 | Replication fork | 2 | 0.028540071 | pcna, tp53 |
CC | 0,032,839 | Dendrite cytoplasm | 2 | 0.030194119 | hip1r, grik3 |
CC | 0,043,234 | Protein complex | 4 | 0.032294565 | cdkn2a, tp53, chaf1a, hist2h4a |
MF | 0,042,802 | Identical protein binding | 8 | 4.19E-04 | s100a2, pcna, tp53, cbs, tyrobp, trim27, chaf1a, tk1 |
MF | 0,004,797 | Thymidine kinase activity | 2 | 0.003787763 | tk2, tk1 |
MF | 0,005,515 | Protein binding | 25 | 0.006734124 | s100a2, hip1r, tle2, rfc2, sp140, nr4a1, tk1, hist2h4a, acan, cacna1c, clc, cbs, gdf15, ap1g2, chaf1a, nck2, pcna, tp53, abcb9, cdkn2a, flii, tyrobp, atp6v1b2, trim27, mapkapk3 |
MF | 0,019,206 | Nucleoside kinase activity | 2 | 0.018800305 | tk2, tk1 |
MF | 0,019,899 | Enzyme binding | 4 | 0.024733293 | pcna, brox, gabrd, iqch |
MF | 0,003,677 | DNA binding | 8 | 0.034312324 | cdkn2a, pcna, tp53,rfc2, sp140, trim27, neu2, hist2h4a |