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Fig. 1 | Journal of Orthopaedic Surgery and Research

Fig. 1

From: High-mobility group box chromosomal protein-1 deletion alleviates osteoporosis in OVX rat model via suppressing the osteoclastogenesis and inflammation

Fig. 1

HMGB-1 deficiency protects against bone structural changes in OVX rat model. a To confirm the success of HMGB-1 knockdown, HMGB-1 mRNA expression levels in main organs of wild-type (WT) and HMGB-1 KD rats were, respectively, determined by qRT-PCR. b, c The trabeculae structures in WT rats and HMGB-1 rats were identified by Micro-CT. *P < 0.05; **P < 0.01; vs WT group. n = 6. Graphs are representative of three biologically independent experiments. Then, all rats were divided into three groups: the WT sham group, the WT OVX group and the HMGB-1 KD OVX group. d, e The mRNA and protein levels of HMGB-1 were, respectively, detected by qRT-PCR and western blotting in each group. f, g The trabeculae structures of all rats were identified by Micro-CT. Error bars indicate SD. *P < 0.05, vs WT Sham group; #P < 0.05, vs WT OVX group. n = 6. Graphs are representative of three biologically independent experiments

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X