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Table 3 Subgroup analysis in studies stratified by pregabalin dose

From: The preemptive effects of oral pregabalin on perioperative pain management in lower limb orthopedic surgery: a systematic review and meta-analysis

Subgroup No. of arms Sample size Mean difference or risk ratio (95% CI) Test for subgroup differences
(pregabalin/placebo) (P value)
Static pain intensity at 24 h
 ≥ 150 mg/day 2 70/52 0.04 [− 0.40, 0.47] 0.3
 < 150 mg/day 9 240/241 − 0.22 [− 0.46, 0.01]  
Dynamic pain intensity at 24 h
 ≥ 150 mg/day 3 97/94 − 0.26 [− 0.89, 0.37] 0.72
 < 150 mg/day 7 180/185 − 0.41 [− 0.91, 0.08]  
Morphine consumption within 24 h
 ≥ 150 mg/day 2 126/122 − 44.06 [− 96.28, 8.16] 0.62
 < 150 mg/day 8 304/301 − 30.12 [− 47.65, − 12.60]  
Nausea
 ≥ 150 mg/day 6 330/334 0.77 [0.60, 0.99] 0.77
 < 150 mg/day 9 359/366 0.72 [0.50, 1.04]  
Vomiting
 ≥ 150 mg/day 4 272/276 0.77 [0.49, 1.21] 0.99
 < 150 mg/day 6 276/277 0.78 [0.44, 1.37]  
Drowsiness
 ≥ 150 mg/day 3 154/156 1.43 [1.02, 1.98] 0.05
 < 150 mg/day 4 339/340 0.95 [0.76, 1.19]  
Dizziness
 ≥ 150 mg/day 3 232/238 1.54 [1.02, 2.31] 0.73
 < 150 mg/day 5 248/250 1.70 [1.13, 2.57]