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Table 3 Associations of COL5A1 gene polymorphisms and musculoskeletal soft tissue injuries

From: Association of COL5A1 gene polymorphisms and musculoskeletal soft tissue injuries: a meta-analysis based on 21 observational studies

Polymorphism/genetic models

Effect size of association

No. of cohorts

Test of heterogeneity

Statistical model

OR

95%CI

P

I2 (%)

P

Rs12722

       

T versus C

       

 Overall

1.14

1.03–1.28

0.01

21

42

0.02

R

 Ligament injury

1.22

1.09–1.38

0.0008

8

0

0.82

F

 Tendon injury

1.08

0.89–1.31

0.44

10

61

0.006

R

 Muscle injury

1.05

0.66–1.68

0.83

2

57

0.13

R

 Caucasian

1.16

1.03–1.31

0.02

17

43

0.03

R

 Asian

1.19

0.75–1.89

0.45

3

61

0.07

R

TT versus CC

       

 Overall

1.33

1.08–1.65

0.008

21

32

0.08

R

 Ligament injury

1.52

1.19–1.95

0.0009

8

0

0.79

F

 Tendon injury

1.19

0.81–1.77

0.37

10

57

0.01

R

 Muscle injury

1.05

0.52–2.13

0.90

2

34

0.22

F

 Caucasian

1.38

1.09–1.76

0.008

17

36

0.07

R

 Asian

0.98

0.46–2.12

0.97

3

27

0.24

F

TC versus CC

       

 Overall

1.24

1.03–1.49

0.02

21

37

0.05

R

 Ligament injury

1.30

1.05–1.62

0.02

8

0

0.93

F

 Tendon injury

1.24

0.85–1.81

0.27

10

61

0.006

R

 Muscle injury

0.92

0.66–1.27

0.62

2

0

0.67

F

 Caucasian

1.27

1.01–1.59

0.04

17

37

0.06

R

 Asian

1.25

0.73–2.14

0.41

3

59

0.09

R

TT + TC versus CC

       

 Overall

1.28

1.08–1.52

0.005

21

37

0.05

R

 Ligament injury

1.37

1.12–1.69

0.002

8

0

0.88

F

 Tendon injury

1.24

0.89–1.74

0.21

10

57

0.01

R

 Muscle injury

0.93

0.68–1.27

0.65

2

0

0.32

F

 Caucasian

1.33

1.08–1.63

0.007

17

33

0.09

R

 Asian

1.27

0.73–2.20

0.40

3

63

0.06

R

TT versus TC + CC

       

 Overall

1.12

0.95–1.35

0.18

21

41

0.03

R

 Ligament injury

1.25

1.04–1.51

0.02

8

0

0.86

F

 Tendon injury

1.00

0.72–1.37

0.98

10

65

0.002

R

 Muscle injury

1.12

0.61–2.05

0.71

2

30

0.23

F

 Caucasian

1.14

0.94–1.38

0.20

17

48

0.01

R

 Asian

0.97

0.45–2.08

0.93

3

9

0.29

F

Rs13946

       

T versus C

       

 Overall

1.09

0.94–1.25

0.25

7

29

0.21

F

 Ligament injury

1.19

1.00–1.42

0.05

4

0

0.80

F

 Tendon injury

0.90

0.53–1.54

0.71

2

74

0.05

R

 Caucasian

1.07

0.92–1.24

0.40

6

37

0.16

F

TT versus CC

       

 Overall

1.25

0.88–1.76

0.21

7

0

0.53

F

 Ligament injury

1.27

0.83–1.96

0.27

4

0

0.47

F

 Tendon injury

1.30

0.67–2.54

0.44

2

58

0.12

 

 Caucasian

1.22

0.83–1.79

0.30

6

1

0.41

F

TC versus CC

       

 Overall

1.31

0.72–2.42

0.38

7

66

0.007

R

 Ligament injury

0.91

0.60–1.39

0.66

4

16

0.31

F

 Tendon injury

3.68

1.94–6.98

 < 0.01

2

0

0.60

F

 Caucasian

1.43

0.70–2.92

0.33

6

69

0.006

R

TT + TC versus CC

       

 Overall

1.28

0.87–1.89

0.21

7

26

0.23

F

 Ligament injury

1.07

0.71–1.61

0.74

4

1

0.39

F

 Tendon injury

2.28

1.23–4.23

0.009

2

0

0.78

F

 Caucasian

1.41

0.98–2.02

0.06

6

35

0.17

F

TT versus TC + CC

       

 Overall

1.02

0.69–1.52

0.91

7

76

0.0003

R

 Ligament injury

1.32

1.05–1.65

0.02

4

0

0.65

F

 Tendon injury

0.54

0.15–1.91

0.34

2

90

0.001

R

 Caucasian

0.96

0.62–1.49

0.85

6

79

0.0003

R

Rs11103544

       

T versus C

0.98

0.61–1.57

0.94

3

75

0.02

R

 TT versus CC

0.74

0.31–1.80

0.51

3

53

0.12

R

 TC versus CC

0.64

0.35–1.17

0.15

3

0

0.47

F

 TT + TC versus CC

0.72

0.41–1.27

0.26

3

40

0.19

F

 TT versus TC + CC

1.06

0.65–1.73

0.81

3

66

0.05

R

Rs71746744

       

I versus D

1.50

1.13–1.99

0.005

3

8

0.34

F

II versus DD

2.04

1.01–4.12

0.05

3

27

0.25

F

ID versus DD

1.21

0.59–2.48

0.61

3

3

0.36

F

II + ID versus DD

1.61

0.81–3.18

0.17

3

27

0.26

F

II versus ID + DD

1.72

1.20–2.46

0.003

3

0

0.67

F

Rs3196378

       

A versus C

1.21

1.03–1.42

0.02

4

0

0.83

F

AA versus CC

1.46

1.05–2.03

0.03

4

0

0.86

F

AC versus CC

1.25

0.94–1.66

0.13

4

20

0.29

F

AA + AC versus CC

1.45

1.11–1.88

0.006

4

0

0.88

F

AA versus AC + CC

1.16

0.88–1.52

0.28

4

0

0.52

F

  1. OR, odds ratio; CI, confidence interval; F, fixed-effects model; R, random-effects model; ATEN, Achilles tendinopathy; ARUP, Achilles tendon rupture; ACLI, anterior cruciate ligament injury; PTEN, patellar tendinopathy; RCT, rotator cuff tear; TTEN, tibial tendinopathy
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Journal of Orthopaedic Surgery and Research

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