Association of COL5A1 gene polymorphisms and musculoskeletal soft tissue injuries: a meta-analysis based on 21 observational studies

Guo, Rui; Ji, Zhe; Gao, Shutao; Aizezi, Aihaiti; Fan, Yong; Wang, Zhigang; Ning, Kai

doi:10.1186/s13018-022-03020-9

Journal of Orthopaedic Surgery and Research

Table 1 Main characteristics of included studies

From: Association of COL5A1 gene polymorphisms and musculoskeletal soft tissue injuries: a meta-analysis based on 21 observational studies

Author	Year	Country	Ethnicity	Gender	Study design	Diagnosis	Case			Control			HWE
Author	Year	Country	Ethnicity	Gender	Study design	Diagnosis	VV	Vv	vv	VV	Vv	vv	HWE
Rs12722							TT	TC	CC	TT	TC	CC
Alakhdar Y	2021	Spain	Caucasian	Both	Case–control	RCTEN	11	31	7	36	47	5	0.04
Alakhdar Y	2020	Spain	Caucasian	Both	Case–control	ETEN	12	20	4	35	58	8	0.02
Altinisik J	2015	Turkey	Caucasian	Both	Cohort	TE	62	46	37	49	85	50	0.31
Brown KL	2017	UK	Caucasian	Both	Case–control	ATP	22	48	29	34	64	27	0.76
Figueiredo EA	2020	Brazil	Mixed	Both	Case–control	RCT	47	94	62	128	248	186	0.01
Haug KBF	2018	Norway	Caucasian	Both	Cohort	PTEN	9	20	4	26	49	18	0.56
Kim H	2015	South Korea	Asian	Both	Case–control	ACLI, RUP	0	15	20	0	8	31	0.48
Leźnicka K	2021	Poland	Caucasian	Both	Case–control	MI	32	12	9	31	16	14	0.01
Longo UG	2018	Italy	Caucasian	Both	Case–control	RCT	33	46	14	74	101	31	0.72
Lulińska-Kuklik E	2018	Poland	Caucasian	Male	Case–control	ACLI	45	66	23	62	107	42	0.74
Miyamoto-Mikami E	2019	Japan	Asian	Both	Cohort	MI	3	52	135	34	400	935	0.26
O'Connell K (I)	2015	South Africa	Caucasian	Both	Case–control	ACLI	72	121	31	65	114	52	0.88
O'Connell K (II)	2015	Poland	Caucasian	Both	Case–control	ACLI	32	44	15	38	75	30	0.54
Raleigh SM	2009	South Africa	Caucasian	Both	Case–control	TEN	29	34	11	25	43	30	0.24
September AV (I)	2009	Australia	Caucasian	Both	Case–control	TEN	17	58	10	74	84	50	0.01
September AV (II)	2009	South Africa	Caucasian	Both	Case–control	TEN	34	47	12	39	55	37	0.07
Sivertsen EA	2019	Norway, Finland	Caucasian	Female	Cohort	ACLI	48	55	15	256	351	124	0.85
Stepien-Slodkowska M	2015	Poland	Caucasian	Both	Case–control	ACLI	48	66	24	53	91	39	0.99
Suijkerbuijk MAM (I)	2019	South Africa	Caucasian	Both	Case–control	ACLI	20	48	25	13	47	36	0.71
Suijkerbuijk MAM (II)	2019	Sweden	Caucasian	Both	Case–control	ACLI	23	36	18	38	47	24	0.20
Zhao D	2020	China	Asian	Both	Cross-sectional	ACLI	8	37	56	6	36	68	0.67
Rs13946							TT	TC	CC	TT	TC	CC
Leźnicka K	2021	Poland	Caucasian	Both	Case–control	MI	26	20	7	28	26	7	0.80
Lulińska-Kuklik E	2018	Poland	Caucasian	Male	Case–control	ACLI	75	49	10	94	102	15	0.07
Mokone GG	2006	South Africa	Caucasian	Both	Case–control	ATP	65	41	5	75	40	14	0.03
September AV (I)	2009	Australia	Caucasian	Both	Case–control	TEN	17	58	9	116	78	50	0.01
Sivertsen EA	2019	Norway, Finland	Caucasian	Female	Cohort	ACLI	70	45	4	410	278	52	0.61
Stepien-Slodkowska M	2015	Poland	Caucasian	Both	Case–control	ACLI	69	57	12	84	88	11	0.06
Zhao D	2020	China	Asian	Both	Cross-sectional	ACLI	39	45	17	32	59	19	0.36
Rs11103544							TT	TC	CC	TT	TC	CC
Figueiredo EA	2020	Brazil	Mixed	Both	Case–control	RCT	147	52	12	182	96	14	0.77
September AV (I)	2009	Australia	Caucasian	Both	Case–control	TEN	55	24	8	140	45	6	0.32
September AV (II)	2009	South Africa	Caucasian	Both	Case–control	TEN	86	35	5	56	29	5	0.63
Rs71746744							II	ID	DD	II	ID	DD
Abrahams Y (I)	2013	South Africa	Caucasian	Both	Case–control	TEN	31	19	1	43	49	9	0.35
Abrahams Y (II)	2013	Australia	Caucasian	Both	Case–control	TEN	25	12	3	45	37	15	0.13
Brown KL	2017	UK	Caucasian	Both	Case–control	ATP	54	45	9	53	67	10	0.08
Rs3196378							AA	AC	CC	AA	AC	CC
Abrahams Y (I)	2013	South Africa	Caucasian	Both	Case–control	TEN	17	42	15	23	50	27	0.99
Abrahams Y (II)	2013	Australia	Caucasian	Both	Case–control	TEN	7	46	10	28	105	42	0.01
Brown KL	2017	UK	Caucasian	Both	Case–control	ATP	34	49	25	33	58	32	0.53
Figueiredo EA	2020	Brazil	Mixed	Both	Case–control	RCT	53	105	53	115	260	189	0.15

V, variant allele; W, wild allele; HWE, Hardy–Weinberg equilibrium; ACLI, anterior cruciate ligament injury; MI, musculoskeletal injury; TE, tennis elbow; RCT, rotator cuff tears; RCTEN, rotator cuff tendinopathy; ETEN, elbow tendinopathy; ATP, Achilles tendon pathology; TEN, Achilles tendinopathy; RUP, Achilles tendon rupture; PTEN, patellar tendinopathy

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ISSN: 1749-799X

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