Table 3 Subgroup analysis for the diagnosis of PJI by D-dimer
Subgroup Analysis | Number of studies | Sensitivity (95% CI) | Specificity (95% CI) | Positive likelihood ratio (95% CI) | Negative likelihood ratio (95% CI) |
|---|---|---|---|---|---|
All studies | 10 | 0.81 [0.71, 0.88] | 0.74 [0.61, 0.84] | 3.1 [2.0, 5.0] | 0.26 [0.16, 0.41] |
Serum samples | 7 | 0.86 [0.76, 0.92] | 0.80 [0.65, 0.89] | 4.2 [2.4, 7.3] | 0.18 [0.11, 0.29] |
China | 8 | 0.76 [0.67, 0.83] | 0.75 [0.65, 0.83] | 3.0 [2.0, 4.5] | 0.32 [0.22, 0.48] |
Threshold value of 850Â ng/ml | 4 | 0.85 [0.69, 0.94] | 0.72 [0.43, 0.90] | 3.0 [1.3, 7.1] | 0.21 [0.09, 0.45] |
Threshold for other | 6 | 0.78 [0.67, 0.86] | 0.75 [0.63, 0.84] | 3.2 [1.9, 5.2] | 0.29 [0.17, 0.49] |
Inflammatory disease exclusion | 6 | 0.76 [0.65, 0.84] | 0.74 [0.62, 0.83] | 2.9 [1.9, 4.4] | 0.33 [0.21, 0.50] |
Inflammatory disease not ruled out | 4 | 0.87 [0.71, 0.95] | 0.75 [0.45, 0.92] | 3.5 [1.3, 9.4] | 0.18 [0.07, 0.42] |
Sample size greater than 100 | 6 | 0.83 [0.68, 0.92] | 0.71 [0.50, 0.85] | 2.8 [1.5, 5.2] | 0.24 [0.12, 0.49] |
Sample size less than 100 | 4 | 0.78 [0.66, 0.86] | 0.80 [0.71, 0.87] | 3.9 [2.5, 6.2] | 0.28 [0.17, 0.45] |