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Table 3 Subgroup analysis for the diagnosis of PJI by D-dimer

From: The accuracy of D-dimer in the diagnosis of periprosthetic infections: a systematic review and meta-analysis

Subgroup Analysis Number of studies Sensitivity (95% CI) Specificity (95% CI) Positive likelihood ratio (95% CI) Negative likelihood ratio (95% CI)
All studies 10 0.81 [0.71, 0.88] 0.74 [0.61, 0.84] 3.1 [2.0, 5.0] 0.26 [0.16, 0.41]
Serum samples 7 0.86 [0.76, 0.92] 0.80 [0.65, 0.89] 4.2 [2.4, 7.3] 0.18 [0.11, 0.29]
China 8 0.76 [0.67, 0.83] 0.75 [0.65, 0.83] 3.0 [2.0, 4.5] 0.32 [0.22, 0.48]
Threshold value of 850 ng/ml 4 0.85 [0.69, 0.94] 0.72 [0.43, 0.90] 3.0 [1.3, 7.1] 0.21 [0.09, 0.45]
Threshold for other 6 0.78 [0.67, 0.86] 0.75 [0.63, 0.84] 3.2 [1.9, 5.2] 0.29 [0.17, 0.49]
Inflammatory disease exclusion 6 0.76 [0.65, 0.84] 0.74 [0.62, 0.83] 2.9 [1.9, 4.4] 0.33 [0.21, 0.50]
Inflammatory disease not ruled out 4 0.87 [0.71, 0.95] 0.75 [0.45, 0.92] 3.5 [1.3, 9.4] 0.18 [0.07, 0.42]
Sample size greater than 100 6 0.83 [0.68, 0.92] 0.71 [0.50, 0.85] 2.8 [1.5, 5.2] 0.24 [0.12, 0.49]
Sample size less than 100 4 0.78 [0.66, 0.86] 0.80 [0.71, 0.87] 3.9 [2.5, 6.2] 0.28 [0.17, 0.45]