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Fig. 6 | Journal of Orthopaedic Surgery and Research

Fig. 6

From: Circ_0001947 promotes cell proliferation, invasion, migration and inflammation and inhibits apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes through miR-671-5p/STAT3 axis

Fig. 6

MiR-671-5p inhibited the progression of RA-FLSs by interacting with STAT3. RA-FLSs were transfected with miR-NC, miR-671-5p, miR-671-5p + pcDNA or miR-671-5p + STAT3. A The protein level of STAT3 in RA-FLSs was measured by western blot assay. B–D The proliferation of RA-FLSs was evaluated by CCK-8 assay and EdU assay. E The apoptosis of RA-FLSs was assessed by flow cytometry analysis. F, G The invasion and migration of RA-FLSs were examined with transwell assay and wound-healing assay, respectively. H The protein levels of CyclinD1 and MMP9 in RA-FLSs were measured by western blot assay. I The concentrations of TNF-α and IL-1β in RA-FLSs were examined with ELISA kits. **P < 0.01, ***P < 0.001, ****P < 0.0001

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Journal of Orthopaedic Surgery and Research

ISSN: 1749-799X