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Fig. 6 | Journal of Orthopaedic Surgery and Research

Fig. 6

From: miR-155 inhibits chondrocyte pyroptosis in knee osteoarthritis by targeting SMAD2 and inhibiting the NLRP3/Caspase-1 pathway

Fig. 6

Knockdown of miR-155 inhibited KOA chondrocyte pyroptosis via the SMAD2/NLRP3/Caspase-1 axis. A The levels of NLRP3 and Caspase-1 were detected by WB; B The cell pyroptosis was detected using the FAM-FLICA Caspase-1 Detection Kit; C The levels of the inflammatory factors IL-1β and IL-18 were detected by ELISA; D The cell viability was detected using the MTT method. The cell experiment was repeated 3 times. The data were expressed as mean ± standard deviation. One-way ANOVA was used for data comparisons among multi-groups. Tukey’s multiple comparisons test was used for the post hoc test. **P < 0.01, ***P < 0.001

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