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Fig. 3 | Journal of Orthopaedic Surgery and Research

Fig. 3

From: miR-155 inhibits chondrocyte pyroptosis in knee osteoarthritis by targeting SMAD2 and inhibiting the NLRP3/Caspase-1 pathway

Fig. 3

miR-155 targeted SMAD2. A The binding sites between miR-155 and SMAD2 WT 3ʹUTR were predicted using the Starbase; B luciferase activity detected by dual-luciferase assay; C The mRNA level of SMAD2 was detected using RT-qPCR; D The protein level of SMAD2 was detected by WB. The cell experiment was repeated 3 times. The data were expressed as mean ± standard deviation. One-way ANOVA was used for data comparisons among multi-groups. Independent t test was adopted for data comparisons between two groups and one-way ANOVA was employed for data comparisons among multi-groups. Tukey’s multiple comparisons test was used for the post hoc test. **P < 0.01, ***P < 0.001

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