Table 4 Comparison of synovial fluid PCR with synovial fluid biomarkers using the MSIS definition based meta-analysis results
References | Test | Location | Number of studies | Sensitivity (95% CI) | Specificity (95% CI) | DOR (95% CI) | AUC |
|---|---|---|---|---|---|---|---|
[26] | Synovial fluid alpha-defensin | Hip, knee, shoulder | 16 | 0.87 (0.83–0.90) | 0.97 (0.96–0.98) | 158.18 (74.26–336.91) | 0.9685 |
[26] | Synovial fluid LE | Hip, knee, shoulder | 12 | 0.87 (0.84–0.90) | 0.96 (0.95–0.97) | 170.09 (97.63–296.32) | 0.9818 |
[27] | Synovial fluid IL-6 | Hip, knee, shoulder | 8 | 0.91 (0.82–0.96) | 0.90 (0.84–0.95) | 101 (28–358) | 0.96 |
[28] | Synovial fluid CRP | Hip, knee | 6 | 0.92 (0.86–0.96) | 0.90 (0.87–0.93) | 101.40 (48.07–213.93) | 0.9663 |
[29] | Synovial fluid WBC count | Hip, knee | 11 | 0.900 (0.872–0.922) | 0.898 (0.814–0.947) | 84.4 (40.3–157) | 0.910 |
[29] | Synovial fluid PMN | Hip, knee | 11 | 0.906 (0.870–0.933) | 0.861 (0.808–0.901) | 62.8 (32.7–109) | 0.940 |
[30] | Synovial fluid culture | Hip, knee | 34 | 0.72 (0.65–0.78) | 0.95 (0.93–0.97) | 52 (31–86) | 0.94 |
Current study | Synovial fluid PCR | Hip, knee | 11 | 0.70 (0.66–0.74) | 0.92 (0.90–0.93) | 37.4 (17.77–78.74) | 0.9252 |