Table 3 Subgroup analysis of synovial fluid PCR
Variable (P value) | Number of studies | Sensitivity (95% CI) | Specificity (95% CI) | ||
|---|---|---|---|---|---|
Adjusted | P value | Adjusted | P value | ||
Reference standard (P = 0.41) | |||||
Diagnostic standard | 9 | 0.73 [0.64–0.83] | P = 0.04 | 0.95 [0.91–0.99] | P = 0.91 |
Others | 4 | 0.85 [0.72–0.98] | 0.94 [0.85–1.00] | ||
Acquisition time (P < 0.001) | |||||
Preoperative | 9 | 0.75 [0.63–0.86] | P = 0.57 | 0.96 [0.91–1.00] | P = 0.26 |
Intraoperative | 2 | 0.77 [0.54–0.99] | 0.93 [0.77–1.00] | ||
Number of patients (P = 0.34) | |||||
Number of patients (> 100) | 6 | 0.71 [0.59–0.83] | P = 0.01 | 0.95 [0.91–1.00] | P = 0.72 |
Number of patients (< 100) | 7 | 0.81 [0.71–0.90] | 0.93 [0.87–1.00] | ||
Antibiotic treatment (P < 0.001) | |||||
Antibiotic treatment (yes) | 5 | 0.73 [0.56–0.89] | P = 0.21 | 0.96 [0.91–1.00] | P = 0.76 |
Antibiotic treatment (no) | 5 | 0.80 [0.66–0.94] | 0.91 [0.82–1.00] | ||
Target gene (P = 0.1) | |||||
16S rRNA | 4 | 0.75 [0.59–0.90] | P = 0.22 | 0.99 [0.96–1.00] | P = 0.14 |
Others | 9 | 0.77 [0.67–0.88] | 0.92 [0.86–0.97] | ||