Table 3 Univariate and multivariate analysis of human albumin infusion in PLIF Perioperative period
Univariable regression | P value | Multivariable regression | P value | |
|---|---|---|---|---|
Age | ||||
< 55 | Ref | Ref | ||
55–75 | 0.962 (0.633, 1.464) | 0.857 | 0.929 (0.584, 1.476) | 0.359 |
> 75 | 6.041 (3.476, 0.499) | < 0.001 | 5.610 (2.950, 10.667) | < 0.001 |
Sex | ||||
Male | 0.955 (0.717, 1.273) | 0.755 | ||
Female | Ref | |||
BMI | 0.96 (0.923, 1.000) | 0.049 | 0.977 (0.935, 1.021) | 0.323 |
Previous history | ||||
Surgery | 0.782 (0.542, 1.126) | 0.186 | ||
Blood transfusion | 0.988 (0.387, 2.522) | 0.980 | ||
Allergies | 1.367 (0.471, 3.966) | 0.566 | ||
Smoking | 1.014 (0.691, 1.489) | 0.944 | ||
Alcohol | 0.927 (0.605, 1.420) | 0.727 | ||
Comorbidities disease | ||||
Hypertension | 1.134 (0.841, 1.529) | 0.408 | ||
T2DM | 1.777 (1.293, 2.442) | < 0.001 | 2.143 (1.493, 3.075) | < 0.001 |
Coronary heart | 1.044 (0.697, 1.563) | 0.836 | ||
Cerebral thrombosis | 1.216 (0.274, 5.388) | 0.797 | ||
Respiratory | 1.032 (0.557, 1.912) | 0.921 | ||
Digestive system | 1.552 (1.010, 2.385) | 0.045 | 1.607 (0.974, 2.651) | 0.050 |
Other | 0.963 (0.629, 1.476) | 0.864 | ||
Laboratory tests | ||||
TP | 1.003 (0.995, 1.011) | 0.491 | ||
GLO | 1.014 (0.977, 1.052) | 0.458 | ||
ALB | 0.867 (0.847, 0.886) | < 0.001 | 0.873 (0.844, 0.903) | < 0.001 |
ALB/GLO | 0.108 (0.072, 0.163) | < 0.001 | 0.883 (0.477, 1.634) | 0.337 |
TBIL | 0.992 (0.969, 1.016) | 0.511 | ||
DBIL | 0.996 (0.933, 1.064) | 0.915 | ||
IBIL | 0.986 (0.954, 1.019) | 0.397 | ||
ALT | 1.004 (0.998, 1.009) | 0.203 | ||
AST | 1.006 (0.995, 1.017) | 0.276 | ||
ALT/AST | 0.928 (0.707, 1.217) | 0.587 | ||
PA | 0.997 (0.995, 1.000) | 0.023 | 0.998 (0.995, 1.000) | 0.202 |
Surgery | ||||
Bleeding volume | 1.001 (1.001, 1.002) | < 0.001 | 1.001 (1.000, 1.002) | < 0.001 |
Time | 1.002 (1.000, 1.004) | 0.030 | 1.002 (1.000, 1.004) | 0.090 |
Indications | ||||
LDH | 0.804 (0.460, 1.403) | 0.442 | ||
LSS | 0.764 (0.428, 1.364) | 0.363 | ||
Spondylolisthesis | Ref | |||
Fusion segment | ||||
1 | Ref | Ref | ||
2 | 1.240 (0.889, 1.729) | 0.206 | 1.127 (0.779, 1.630) | 0.526 |
≥ 3 | 2.245 (1.538, 3.277) | < 0.001 | 1.734 (1.117, 2.691) | 0.014 |