Fig. 9
From: Doxorubicin inhibits osteosarcoma progression by regulating circ_0000006/miR-646/ BDNF axis
Circ_0000006 knockdown repressed tumor growth by upregulating miR-646 and downregulating BDNF expression in vivo. A The effect of circ_0000006 silencing on tumor volume was determined. B The effects of circ_0000006 knockdown on tumor size and weight were revealed in vivo. C The efficiency of circ_0000006 knockdown was detected by qRT-PCR in vivo. D The effect of circ_0000006 depletion on miR-646 expression was illustrated by qRT-PCR in vivo. E Western blot was performed to investigate the influence of circ_0000006 repression on the protein expression of BDNF in vivo. *P < 0.05