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Table 2 Subgroup analysis to investigate the effect of the type of vitamin K on the effect size of vitamin K combined with calcium on 431 lumbar spines BMD

From: The combined effect of vitamin K and calcium on bone mineral density in humans: a meta-analysis of randomized controlled trials

Subgroup Studies SMD (95% CI) I2 (%) P
Vitamin K type     
 K1 5 0.14 (− 0.02 to 0.29) 65.4 0.021
 K2 5 0.30 (0.10 to 0.51) 0 0.429
Vitamin K dose     
 ≤ 100 μg 5 0.40 (0.20 to 0.61) 49.9 0.092
 > 100 μg 5 0.08 (− 0.08 to 0.23) 0 0.584
Calcium dose     
 ≤ 1000 mg 7 0.19 (0.05 to 0.32) 62.3 0.014
 > 1000 mg 3 0.26 (− 0.04 to 0.55) 0 0.644
Follow-up time     
 ≤ 1 year 6 0.38 (0.19 to 0.57) 40 0.139
 > 1 year 4 0.06 (− 0.10 to 0.22) 0 0.496
Gender     
 Female 8 0.26 (0.11 to 0.41) 52.5 0.040
 Both 2 0.08 (− 0.14 to 0.29) 0 0.573