Table 5 Association between polymorphisms of COL1A1, COL11A1 and disc generation susceptibility
Polymorphism | No. of studies | Pooled effect size | Heterogeneity | ||
|---|---|---|---|---|---|
OR (95% CI) | P | I2 (%) | P | ||
COL1A1 Sp1, rs1800012 | Â | Â | Â | Â | Â |
T vs G | 4 | 1.28 (1.00–1.64) | 0.047 | 0 | 0.679 |
TT + GT vs GG | 4 | 1.06 (0.79–1.43) | 0.671 | 0 | 0.974 |
TT vs GG + GT | 4 | 3.66 (1.96–6.85) |  < 0.001 | 0 | 0.775 |
TT vs GG | 4 | 3.40 (1.80–6.40) |  < 0.001 | 0 | 0.823 |
COL11A1 C4603T, rs1676486 | Â | Â | Â | Â | Â |
T vs C | 8 | 1.33 (1.20–1.48) |  < 0.001 | 4.0 | 0.399 |
TT + CT vs CC | 7 | 1.45 (1.26–1.67) |  < 0.001 | 0 | 0.600 |
TT vs CC + CT | 7 | 1.55 (1.21–1.98) | 0.001 | 23.3 | 0.251 |
TT vs CC | 7 | 1.81 (1.40–2.34) |  < 0.001 | 19.7 | 0.279 |