Fig. 1

Identification of DEGs in human osteoblasts exposed to DEX. a Volcano plot analysis of 258 DEGs. The red dots represent the upregulated DEGs, green dots represent downregulated DEGs, and black dots represent genes with no significant change in expression. b Heatmap graphs of the DEGs in the experimental groups: DEX versus control. Arbitrary signal intensity acquired from the microarray analysis is represented by the colors (green = lower expression; red = higher expression). Log2 signal intensity values for any single gene were resized to row Z-score scales. c Top 10 significantly enriched GO terms of DEGs. The x-axis represents the − log10 (P value) associated with GO terms, and the y-axis represents the significantly enriched GO terms. d A bubble chart showing the identified KEGG pathways. The abscissa represents the GeneRatio, and the ordinate represents the KEGG pathway terms. P values indicate larger values from blue through to red, and a larger node size represents a higher number of enriched genes