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Table 3 Treatment characteristics in each study

From: Effectiveness of diluted povidone-iodine lavage for preventing periprosthetic joint infection: an updated systematic review and meta-analysis

Author and year Year Preoperative Prophylaxis Intraoperative Intervention Treatment Intraoperative Control Treatment Postoperative Prophylaxis
Calkins et al 2020 NR 500 ml dilute betadine solution for 3min with of the consisted of 17.5ml PI and 500ml NaCl after implantation, followed by 1L NaCl. Also, the wound edges were painted with 10% PI with a sponge stick 1-L pulsatile lavage of normal saline irrigation NR
Driesman et al 2020 Ancef or vancomycin (depending on MRSA risk) 500 ml of the dilute betadine solution made of 17.5ml PI and 500ml NaCl for 3min after implantation agents chlorhexidine irrigation in-wound antibiotics in the form of 2 g of vancomycin powder
Hernandez et al 2019 Cefazolin (vancomycin or clindamycin if allergic). dilute PI solution for 3 minutes NR Cefazolin (vancomycin or clindamycin if allergic) for 24 hours
Slullitel et al 2020 cefazolin or vancomycin if allergic one surgeon used a 115ml nonsterile bottle of 10% PI diluted in 500ml of sterile saline (0.45%) for 3 minutes.
9 surgeons used a 22.5-mL sterile solution pouch of 10% PI diluted in 250-500 mL of saline (0.2%-0.35%) for 1-3 minutes.
500ml of sterile saline solution before wound closure cefazolin or vancomycin if allergic for 24 hours
Hart et al 2019 NR 1L of sterile 0.25% PI 3 minutes followed by irrigation with normal saline solution prior to closure. NR IV for 24 hours
Fleischman et al 2018 NR Intraoperative dilute betadine irrigation NR systemic antibiotic prophylaxis
Frisch et al 2017 vancomycin and cefazolin (gentamicin if allergic) intraoperative irrigation with 0.9% saline followed by a 2-minute soak with <2% dilute PI which was washed out entirely before closure intraoperative irrigation with 0.9% saline and periodic 0.05% CHG solution followed by a final 1-minute soak in CHG with immediate closure afterward cefazolin was given for 2 doses to be discontinued within 24 hours
Brown et al 2012 cefazolin within 1 hour. 500mL 0.35% PI solution for 3min after implantation, followed by 1L 0.9% NaCl pulsatile lavage with PI painting 1L isotonic sodium chloride solution irrigation Cefazolin (vancomycin or clindamycin if allergic) for 24 hours
  1. Abbreviations: PI Povidone-Iodine, IV intravenous, MRSA methicillin-resistant Staphylococcus aureus, NR not reported